Genetic or Other Causation Should Not Change the Clinical Diagnosis of Cerebral Palsy.
causation
cerebral palsy
clinical definition
genomics
Journal
Journal of child neurology
ISSN: 1708-8283
Titre abrégé: J Child Neurol
Pays: United States
ID NLM: 8606714
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
10
4
2019
medline:
23
6
2020
entrez:
10
4
2019
Statut:
ppublish
Résumé
High throughput sequencing is discovering many likely causative genetic variants in individuals with cerebral palsy. Some investigators have suggested that this changes the clinical diagnosis of cerebral palsy and that these individuals should be removed from this diagnostic category. Cerebral palsy is a neurodevelopmental disorder diagnosed on clinical signs, not etiology. All nonprogressive permanent disorders of movement and posture attributed to disturbances that occurred in the developing fetal and infant brain can be described as "cerebral palsy." This definition of cerebral palsy should not be changed, whatever the cause. Reasons include stability, utility and accuracy of cerebral palsy registers, direct access to services, financial and social support specifically offered to families with cerebral palsy, and community understanding of the clinical diagnosis. Other neurodevelopmental disorders, for example, epilepsy, have not changed the diagnosis when genomic causes are found. The clinical diagnosis of cerebral palsy should remain, should prompt appropriate genetic studies and can subsequently be subclassified by etiology.
Identifiants
pubmed: 30963790
doi: 10.1177/0883073819840449
pmc: PMC6582263
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
472-476Subventions
Organisme : Department of Health
ID : RP-2016-07-019
Pays : United Kingdom
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