DLA class II haplotypes show sex-specific associations with primary hypoadrenocorticism in Standard Poodle dogs.
Autoimmune disease
Canine
DLA
Hypoadrenocorticism
Major histocompatibility complex class II
Journal
Immunogenetics
ISSN: 1432-1211
Titre abrégé: Immunogenetics
Pays: United States
ID NLM: 0420404
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
05
12
2018
accepted:
27
03
2019
pubmed:
11
4
2019
medline:
24
9
2019
entrez:
11
4
2019
Statut:
ppublish
Résumé
Addison's disease (AD) is a life-threatening endocrine disorder that occurs spontaneously in both humans and dogs. Associations between MHC class II genes and AD have been shown in several human studies. Our goal was to identify MHC class II associations with AD in a large population of Standard Poodles, a breed highly predisposed to AD. We sequenced exon 2 of the class II genes DLA-DRB1, DLA-DQA1, and DLA-DQB1 in 110 affected and 101 unaffected Standard Poodles and tested for association with AD. After correcting for population structure, two haplotypes were found to confer risk of developing AD in a sex-specific manner: DLA-DRB1*015:01-DQA1*006:01-DQB1*023:01 in males (x
Identifiants
pubmed: 30968193
doi: 10.1007/s00251-019-01113-0
pii: 10.1007/s00251-019-01113-0
doi:
Substances chimiques
Histocompatibility Antigens Class II
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
373-382Références
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