Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses.

Acetates / pharmacology Cell Differentiation / drug effects Cells, Cultured Humans Interleukin-17 / physiology Keratinocytes / immunology Nuclear Receptor Subfamily 1, Group F, Member 3 / antagonists & inhibitors STAT3 Transcription Factor / physiology Signal Transduction / physiology Skin / pathology Th17 Cells / cytology Tyramine / analogs & derivatives
IL-17 T helper 17 differentiation autoimmunity keratinocytes nuclear hormone receptor retinoic acid receptor-related-orphan-receptor-gamma t skin inflammation

Journal

Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960

Informations de publication

Date de publication:
2019
Historique:
received: 14 11 2018
accepted: 04 03 2019
entrez: 12 4 2019
pubmed: 12 4 2019
medline: 14 7 2020
Statut: epublish

Résumé

The nuclear hormone receptor retinoic acid receptor-related-orphan-receptor-gamma t (RORγt) is the key transcription factor required for Th17 cell differentiation and for production of IL-17 family cytokines by innate and adaptive immune cells. Dysregulated Th17 immune responses have been associated with the pathogenesis of several inflammatory and autoimmune diseases such as psoriasis, psoriatic arthritis, and ankylosing spondylitis. In this article, we describe the

Identifiants

DOI: 10.3389/fimmu.2019.00577 PMID: 30972071 PMC: PMC6443933
pubmed: 30972071
doi: 10.3389/fimmu.2019.00577
pmc: PMC6443933
doi:

Substances chimiques

2-(4-acetoxyphenyl)-2-chloro-N-methylethylamine 0
Acetates 0
Interleukin-17 0
Nuclear Receptor Subfamily 1, Group F, Member 3 0
RORC protein, human 0
STAT3 Transcription Factor 0
Tyramine X8ZC7V0OX3

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

577

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Auteurs

Florence Ecoeur (F)

Autoimmunity, Transplantation, and Inflammation Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland.

Jessica Weiss (J)

Autoimmunity, Transplantation, and Inflammation Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland.

Klemens Kaupmann (K)

Autoimmunity, Transplantation, and Inflammation Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland.

Samuel Hintermann (S)

Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, Switzerland.

David Orain (D)

Global Discovery Chemistry, Novartis Institutes for BioMedical Research, Basel, Switzerland.

Christine Guntermann (C)

Autoimmunity, Transplantation, and Inflammation Disease Area, Novartis Institutes for BioMedical Research, Basel, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Lipides › Acides gras › Acides gras volatils › Acétates › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Cellules › Cellules cultivées › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-17 › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Cellules › Cellules épithéliales › Kératinocytes › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Membre-3 du groupe F de la sous-famille-1 de récepteurs nucléaires › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Facteur de transcription STAT-3 › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Système tégumentaire › Peau › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Antagonizing Retinoic Acid-Related-Orphan...
questionsmedicales.fr › Composés chimiques organiques › Amines › Amines biogènes › Monoamines biogènes › Tyramine › Antagonizing Retinoic Acid-Related-Orphan...