Feedforward regulation of Myc coordinates lineage-specific with housekeeping gene expression during B cell progenitor cell differentiation.
Animals
B-Lymphocytes
/ cytology
Cell Cycle
/ physiology
Cell Differentiation
/ genetics
Cell Lineage
Databases, Genetic
Down-Regulation
Gene Expression Regulation
Genes, Essential
Genes, myc
Humans
Ikaros Transcription Factor
/ metabolism
Lymphocyte Activation
Mice
Precursor Cells, B-Lymphoid
/ cytology
Transcription Factors
/ metabolism
Journal
PLoS biology
ISSN: 1545-7885
Titre abrégé: PLoS Biol
Pays: United States
ID NLM: 101183755
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
29
04
2018
accepted:
16
03
2019
revised:
24
04
2019
pubmed:
13
4
2019
medline:
7
1
2020
entrez:
13
4
2019
Statut:
epublish
Résumé
The differentiation of self-renewing progenitor cells requires not only the regulation of lineage- and developmental stage-specific genes but also the coordinated adaptation of housekeeping functions from a metabolically active, proliferative state toward quiescence. How metabolic and cell-cycle states are coordinated with the regulation of cell type-specific genes is an important question, because dissociation between differentiation, cell cycle, and metabolic states is a hallmark of cancer. Here, we use a model system to systematically identify key transcriptional regulators of Ikaros-dependent B cell-progenitor differentiation. We find that the coordinated regulation of housekeeping functions and tissue-specific gene expression requires a feedforward circuit whereby Ikaros down-regulates the expression of Myc. Our findings show how coordination between differentiation and housekeeping states can be achieved by interconnected regulators. Similar principles likely coordinate differentiation and housekeeping functions during progenitor cell differentiation in other cell lineages.
Identifiants
pubmed: 30978178
doi: 10.1371/journal.pbio.2006506
pii: pbio.2006506
pmc: PMC6481923
doi:
Substances chimiques
Transcription Factors
0
Ikaros Transcription Factor
148971-36-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e2006506Subventions
Organisme : Medical Research Council
ID : MC_U120027516
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1102/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 099276/Z/12/Z
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Development. 2016 Dec 1;143(23):4301-4311
pubmed: 27899507
Bioinformatics. 2006 May 1;22(9):1096-102
pubmed: 16481333
Nat Immunol. 2012 Jan 22;13(3):300-7
pubmed: 22267219
J Exp Med. 2011 Jul 4;208(7):1367-76
pubmed: 21708926
Nat Immunol. 2014 Mar;15(3):283-93
pubmed: 24509509
BMC Genomics. 2008 Jul 31;9:363
pubmed: 18671852
Genome Biol. 2016 Jan 26;17:13
pubmed: 26813401
N Engl J Med. 2009 Jan 29;360(5):470-80
pubmed: 19129520
Pediatr Blood Cancer. 2014 Oct;61(10):1779-85
pubmed: 24976218
Immunity. 2011 Dec 23;35(6):871-82
pubmed: 22195744
N Engl J Med. 2014 Sep 11;371(11):1005-15
pubmed: 25207766
Bioinformatics. 2012 Mar 15;28(6):882-3
pubmed: 22257669
Blood. 2013 Mar 7;121(10):1769-82
pubmed: 23303821
Nat Immunol. 2014 Mar;15(3):294-304
pubmed: 24509510
J Immunol. 2011 Mar 1;186(5):3047-57
pubmed: 21307297
Cell. 2012 Oct 12;151(2):289-303
pubmed: 23021777
Cell. 2011 Sep 2;146(5):772-84
pubmed: 21871655
Genes Chromosomes Cancer. 2009 Jan;48(1):22-38
pubmed: 18803328
BMC Bioinformatics. 2016 Nov 22;17(Suppl 15):427
pubmed: 28185573
Cell. 2014 Sep 11;158(6):1309-1323
pubmed: 25215489
Nat Immunol. 2010 Jul;11(7):635-43
pubmed: 20543837
Nature. 2008 May 1;453(7191):110-4
pubmed: 18408710
J Exp Med. 2013 Dec 16;210(13):2823-32
pubmed: 24297995
Nature. 2012 Sep 6;489(7414):52-5
pubmed: 22955614
Exp Hematol. 2017 Feb;46:1-8
pubmed: 27865806
Bioinformatics. 2011 Jun 15;27(12):1739-40
pubmed: 21546393
Nat Protoc. 2012 Mar 01;7(3):562-78
pubmed: 22383036
J Exp Med. 2017 Mar 6;214(3):793-814
pubmed: 28190001
J Exp Med. 2014 Aug 25;211(9):1857-74
pubmed: 25073789
EMBO J. 2012 Jun 05;31(14):3130-46
pubmed: 22669466
Nat Rev Cancer. 2015 Oct;15(10):593-607
pubmed: 26383138
Lancet Oncol. 2009 Feb;10(2):125-34
pubmed: 19138562
Cell Cycle. 2016;15(2):196-212
pubmed: 26825227
BMC Bioinformatics. 2009 May 27;10:161
pubmed: 19473525
J Exp Med. 2018 Oct 1;215(10):2586-2599
pubmed: 30158115
Nature. 2016 Jun 08;534(7607):391-5
pubmed: 27281220
PLoS Comput Biol. 2016 Dec 28;12(12):e1005274
pubmed: 28030541
J Exp Med. 2017 Mar 6;214(3):773-791
pubmed: 28190000
J Cell Sci. 2006 May 15;119(Pt 10):2065-72
pubmed: 16638804
Cancer Cell. 2015 Sep 14;28(3):343-56
pubmed: 26321221
PLoS One. 2012;7(7):e40934
pubmed: 22848414
Elife. 2017 Mar 20;6:
pubmed: 28318487
Blood. 2013 Oct 10;122(15):2622-9
pubmed: 23974192
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Nature. 2016 Jan 14;529(7585):216-20
pubmed: 26735015
Genome Biol. 2014 Feb 03;15(2):R29
pubmed: 24485249
Nat Methods. 2012 Mar 04;9(4):357-9
pubmed: 22388286
Mol Cell Biol. 2010 Sep;30(17):4149-58
pubmed: 20566697
Nat Rev Immunol. 2016 Sep;16(9):553-65
pubmed: 27396447
Trends Cell Biol. 2013 Oct;23(10):484-92
pubmed: 23756093
J Exp Med. 1991 May 1;173(5):1213-25
pubmed: 1827140
Nat Biotechnol. 2014 Apr;32(4):381-386
pubmed: 24658644
JCI Insight. 2016;1(4):
pubmed: 27123491
Immunity. 2007 Mar;26(3):335-44
pubmed: 17363301
Blood. 2013 Jul 18;122(3):413-23
pubmed: 23704093
BMC Bioinformatics. 2016 Jun 06;17 Suppl 5:206
pubmed: 27295177
Nature. 2013 Apr 25;496(7446):461-8
pubmed: 23467089
Immunity. 2007 Mar;26(3):323-33
pubmed: 17331747
Proc Natl Acad Sci U S A. 2012 Dec 18;109(51):21028-33
pubmed: 23213261
Cell. 2017 Jan 26;168(3):442-459.e20
pubmed: 28111071
Genome Biol. 2013 Apr 25;14(4):R36
pubmed: 23618408
Nucleic Acids Res. 2013 Nov;41(21):e201
pubmed: 24071585
Cell. 2012 Jul 20;150(2):279-90
pubmed: 22817891
Nat Rev Immunol. 2014 Feb;14(2):69-80
pubmed: 24378843
Curr Top Microbiol Immunol. 1996;217:45-59
pubmed: 8787617
Blood. 2010 Dec 2;116(23):4874-84
pubmed: 20699438
Nat Rev Immunol. 2009 Mar;9(3):195-205
pubmed: 19240758
Cancer Cell. 2005 Apr;7(4):375-86
pubmed: 15837626