Potential Pharmacokinetic Drug⁻Drug Interaction Between Harmine, a Cholinesterase Inhibitor, and Memantine, a Non-Competitive
Alzheimer’s disease
drug-drug interaction
harmine
liquid chromatography-mass spectrometry
memantine
pharmacokinetics
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
11 Apr 2019
11 Apr 2019
Historique:
received:
18
03
2019
revised:
09
04
2019
accepted:
10
04
2019
entrez:
14
4
2019
pubmed:
14
4
2019
medline:
1
8
2019
Statut:
epublish
Résumé
Harmine (HAR) is a beta-carboline alkaloid widely distributed in nature. It exhibits psychopharmacological effects of improving learning and memory. However, excessive dose of HAR can cause central tremor toxicity, which may be related to the glutamate system. Memantine (MEM) is a non-competitive
Identifiants
pubmed: 30978991
pii: molecules24071430
doi: 10.3390/molecules24071430
pmc: PMC6479946
pii:
doi:
Substances chimiques
Cholinesterase Inhibitors
0
Receptors, N-Methyl-D-Aspartate
0
Harmine
4FHH5G48T7
Memantine
W8O17SJF3T
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : the National Nature Science Foundation of China
ID : 81872933
Organisme : the National Natural Science Foundation of China and Xinjiang Uygur Autonomous Region of China
ID : U1130303
Organisme : the Key Project of Ministry of Science and Technology of China
ID : 2017ZX09301068-004-001
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