Fetal anogenital distance using ultrasound.
Adult
Anal Canal
/ anatomy & histology
Body Weights and Measures
/ methods
Female
Fetal Growth Retardation
/ diagnosis
Fetus
/ anatomy & histology
Genitalia
/ anatomy & histology
Gestational Age
Humans
Israel
Male
Penis
/ anatomy & histology
Perineum
/ anatomy & histology
Pregnancy
Scrotum
/ anatomy & histology
Sex Characteristics
Sex Determination Analysis
/ methods
Ultrasonography, Prenatal
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
09
01
2019
revised:
02
04
2019
accepted:
10
04
2019
pubmed:
14
4
2019
medline:
1
5
2020
entrez:
14
4
2019
Statut:
ppublish
Résumé
This study measured anogenital distance (AGD) during late second/early third trimester of pregnancy to confirm previous findings that AGD can be measured noninvasively in the fetus using ultrasound and further showed differences in reference ranges between populations. Two hundred ten singleton pregnancies were recruited at the Rosie Hospital, Cambridge, UK. A 2D ultrasound was performed between 26 and 30 weeks of pregnancy. AGD was measured from the centre of the anus to the base of the scrotum in males and to the posterior convergence of the fourchette in females. A significant difference in AGD between males and females (P < .0001) was found, replicating previous results with a significant correlation between estimated fetal weight (EFW) and AGD in males only (P = .006). A comparison of AGD using reference data from an Israeli sample (n = 118) and our UK sample (n = 208) showed a significant difference (P < .0001) in both males and females, after controlling for gestational age (GA). Our results confirm that AGD measurement in utero using ultrasound is feasible. In addition, there are strong sex differences, consistent with previous suggestions that AGD is influenced by prenatal androgen exposure. AGD lengths differ between the UK and Israel; therefore, population-specific normative values may be required for accurate clinical assessments.
Identifiants
pubmed: 30980419
doi: 10.1002/pd.5459
pmc: PMC6618155
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
527-535Subventions
Organisme : Department of Health
ID : Senior Investigator Award to Simon Baron-Cohen
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Informations de copyright
© 2019 The Authors. Prenatal Diagnosis Published by John Wiley & Sons Ltd.
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