Glucose Responsiveness of β-Cells Depends on Fatty Acids.

Aniline Compounds / pharmacology Animals Calcium / metabolism Cattle Cell Line, Tumor Fatty Acids, Nonesterified / metabolism Glucose / pharmacology Humans Insulin / metabolism Insulin-Secreting Cells / drug effects Insulinoma Mice Palmitates / pharmacology Phenylpropionates / pharmacology

Journal

Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
ISSN: 1439-3646
Titre abrégé: Exp Clin Endocrinol Diabetes
Pays: Germany
ID NLM: 9505926

Informations de publication

Date de publication:
Oct 2020
Historique:
pubmed: 16 4 2019
medline: 29 7 2021
entrez: 16 4 2019
Statut: ppublish

Résumé

Glucose-stimulated insulin secretion (GSIS) is the gold standard for β-cell function. Both experimental and clinical diabetology, i. e., preceding transplantation of isolated human islets, depend on functional testing. However, multiple factors influence GSIS rendering the comparison of different

Identifiants

DOI: 10.1055/a-0884-2919 PMID: 30986881
pubmed: 30986881
doi: 10.1055/a-0884-2919
doi:

Substances chimiques

Aniline Compounds 0
Fatty Acids, Nonesterified 0
Insulin 0
Palmitates 0
Phenylpropionates 0
TUG-469 0
Glucose IY9XDZ35W2
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

644-653

Subventions

Organisme : 01GI0925
ID : German Center for Diabetes Research
Organisme : 01GI0925
ID : IZKF-Promotionskolleg of the Faculty of Medicine, University of Tuebingen
Organisme : 31-2008-416
ID : Human islets were provided through the JDRF

Informations de copyright

Thieme. All rights reserved.

Déclaration de conflit d'intérêts

The authors declare that they have no conflict of interest.

Auteurs

Felicia Gerst (F)

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard-Karls-University of Tuebingen, Tübingen, Germany.
Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of Tuebingen, Tübingen, Germany.
German Center for Diabetes Research (DZD e.V.).

Christine Singer (C)

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard-Karls-University of Tuebingen, Tübingen, Germany.

Katja Noack (K)

Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Tuebingen, Tuebingen, Germany.

Dunia Graf (D)

Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Tuebingen, Tuebingen, Germany.

Gabriele Kaiser (G)

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard-Karls-University of Tuebingen, Tübingen, Germany.
Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of Tuebingen, Tübingen, Germany.
German Center for Diabetes Research (DZD e.V.).

Madhura Panse (M)

Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of Tuebingen, Tübingen, Germany.

Marketa Kovarova (M)

Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of Tuebingen, Tübingen, Germany.

Erwin Schleicher (E)

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard-Karls-University of Tuebingen, Tübingen, Germany.
Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of Tuebingen, Tübingen, Germany.
German Center for Diabetes Research (DZD e.V.).

Hans-Ulrich Häring (HU)

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard-Karls-University of Tuebingen, Tübingen, Germany.
Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of Tuebingen, Tübingen, Germany.
German Center for Diabetes Research (DZD e.V.).

Gisela Drews (G)

Department of Pharmacology and Toxicology, Institute of Pharmacy, University of Tuebingen, Tuebingen, Germany.

Susanne Ullrich (S)

Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the Eberhard-Karls-University of Tuebingen, Tübingen, Germany.
Department of Internal Medicine IV, Division of Endocrinology, Diabetology and Nephrology, University Hospital of Tuebingen, Tübingen, Germany.
German Center for Diabetes Research (DZD e.V.).

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Classifications MeSH

questionsmedicales.fr › Composés chimiques organiques › Amines › Dérivés de l'aniline › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Eucaryotes › Animaux › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Artiodactyla › Ruminants › Bovins › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Lipides › Acides gras › Acide gras libre › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Glucides › Sucres › Oses › Hexose › Glucose › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules entéroendocrines › Cellules à insuline › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Maladies endocriniennes › Tumeurs des glandes endocrines › Tumeurs du pancréas › Adénome langerhansien › Insulinome › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Lipides › Acides gras › Acides palmitiques › Palmitates › Glucose Responsiveness of β-Cells Depends on...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Acides carbocycliques › Phénylpropionates › Glucose Responsiveness of β-Cells Depends on...