NR2E3 is a key component in p53 activation by regulating a long noncoding RNA DINO in acute liver injuries.
Acetaminophen
/ adverse effects
Acetylcysteine
/ pharmacology
Animals
Chemical and Drug Induced Liver Injury
/ genetics
Epigenesis, Genetic
/ drug effects
Hep G2 Cells
Humans
Liver Failure, Acute
/ chemically induced
Mice
Mice, Knockout
Orphan Nuclear Receptors
/ genetics
RNA, Long Noncoding
/ biosynthesis
Signal Transduction
Tumor Suppressor Protein p53
/ genetics
DINO
NR2E3
long noncoding RNA
p53
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
pubmed:
17
4
2019
medline:
20
5
2020
entrez:
17
4
2019
Statut:
ppublish
Résumé
Damage-induced long noncoding RNA (DINO) is a long noncoding RNA that directly interacts with p53 and thereby enhances p53 stability and activity in response to various cellular stresses. Here, we demonstrate that nuclear receptor subfamily 2 group E member 3 (NR2E3) plays a crucial role in maintaining active DINO epigenetic status for its proper induction and subsequent p53 activation. In acetaminophen (APAP)- or carbon tetrachloride-induced acute liver injuries, NR2E3 knockout (KO) mice exhibited far more severe liver injuries due to impaired DINO induction and p53 activation. Mechanistically, NR2E3 loss both
Identifiants
pubmed: 30991008
doi: 10.1096/fj.201801881RR
pmc: PMC6593879
doi:
Substances chimiques
Nr2e3 protein, mouse
0
Orphan Nuclear Receptors
0
RNA, Long Noncoding
0
Trp53 protein, mouse
0
Tumor Suppressor Protein p53
0
Acetaminophen
362O9ITL9D
Acetylcysteine
WYQ7N0BPYC
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
8335-8348Subventions
Organisme : NIEHS NIH HHS
ID : P30 ES006096
Pays : United States
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