An apically located hybrid guanylate cyclase-ATPase is critical for the initiation of Ca
Adenosine Triphosphatases
/ genetics
Calcium
/ metabolism
Calcium Ionophores
/ pharmacology
Calcium Signaling
/ drug effects
Cyclic GMP
/ metabolism
Cytosol
/ metabolism
Guanylate Cyclase
/ antagonists & inhibitors
Hydrogen-Ion Concentration
Oligonucleotides, Antisense
/ metabolism
Potassium
/ metabolism
Protozoan Proteins
/ antagonists & inhibitors
Pyrazoles
/ pharmacology
Pyrimidinones
/ pharmacology
Toxoplasma
/ growth & development
Toxoplasma gondii
calcium
cell motility
cyclic GMP (cGMP)
cyclic nucleotide
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
31 05 2019
31 05 2019
Historique:
received:
22
08
2018
revised:
12
04
2019
pubmed:
18
4
2019
medline:
19
2
2020
entrez:
18
4
2019
Statut:
ppublish
Résumé
Protozoan parasites of the phylum Apicomplexa actively move through tissue to initiate and perpetuate infection. The regulation of parasite motility relies on cyclic nucleotide-dependent kinases, but how these kinases are activated remains unknown. Here, using an array of biochemical and cell biology approaches, we show that the apicomplexan parasite
Identifiants
pubmed: 30992368
pii: S0021-9258(20)36414-0
doi: 10.1074/jbc.RA118.005491
pmc: PMC6552420
doi:
Substances chimiques
5-benzyl-3-isopropyl-1H-pyrazolo(4,3-d)pyrimidin-7(6H)-one
0
Calcium Ionophores
0
Oligonucleotides, Antisense
0
Protozoan Proteins
0
Pyrazoles
0
Pyrimidinones
0
Adenosine Triphosphatases
EC 3.6.1.-
Guanylate Cyclase
EC 4.6.1.2
Cyclic GMP
H2D2X058MU
Potassium
RWP5GA015D
Calcium
SY7Q814VUP
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8959-8972Informations de copyright
© 2019 Yang et al.
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