Metabolic fingerprinting of chorionic villous samples in normal pregnancy and chromosomal disorders.
Journal
Prenatal diagnosis
ISSN: 1097-0223
Titre abrégé: Prenat Diagn
Pays: England
ID NLM: 8106540
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
22
02
2019
revised:
28
03
2019
accepted:
14
04
2019
pubmed:
18
4
2019
medline:
2
7
2020
entrez:
18
4
2019
Statut:
ppublish
Résumé
Placenta-related biological samples are used in biomedical research to investigate placental development. Metabolomics represents a promising approach for studying placental metabolism in an effort to explain physiological and pathological mechanisms. The aim of this study was to investigate metabolic changes in chorionic villi during the first trimester of pregnancy in euploid and aneuploid cases. Samples from 21 women (13 euploid and eight aneuploid) were analyzed with A regression model to test the correlation between fetal crown-rump length (CRL) and metabolic profile of chorionic villi was performed in euploid pregnancies (R Polyol pathways may have a crucial role in energy production in early pregnancy. Excessive activation in aneuploid pregnancies may lead to increased oxidative stress. Metabolomics represents a promising approach to investigate placental metabolic changes.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
848-858Informations de copyright
© 2019 John Wiley & Sons, Ltd.
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