Multivariate genome-wide association study of rapid automatised naming and rapid alternating stimulus in Hispanic American and African-American youth.
Black or African American
/ genetics
Alleles
Computational Biology
/ methods
Dyslexia
/ diagnosis
Epigenesis, Genetic
Female
Genetic Association Studies
Genetic Predisposition to Disease
Genome, Human
Genome-Wide Association Study
/ methods
Genomics
/ methods
Hispanic or Latino
/ genetics
Humans
Linkage Disequilibrium
Male
Meta-Analysis as Topic
Neuroimaging
Polymorphism, Single Nucleotide
Quantitative Trait, Heritable
complex traits
epigenetics
genome-wide
psychiatry
Journal
Journal of medical genetics
ISSN: 1468-6244
Titre abrégé: J Med Genet
Pays: England
ID NLM: 2985087R
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
13
11
2018
revised:
12
03
2019
accepted:
19
03
2019
pubmed:
19
4
2019
medline:
4
6
2020
entrez:
19
4
2019
Statut:
ppublish
Résumé
Rapid automatised naming (RAN) and rapid alternating stimulus (RAS) are reliable predictors of reading disability. The underlying biology of reading disability is poorly understood. However, the high correlation among RAN, RAS and reading could be attributable to shared genetic factors that contribute to common biological mechanisms. To identify shared genetic factors that contribute to RAN and RAS performance using a multivariate approach. We conducted a multivariate genome-wide association analysis of RAN Objects, RAN Letters and RAS Letters/Numbers in a sample of 1331 Hispanic American and African-American youth. Follow-up neuroimaging genetic analysis of cortical regions associated with reading ability in an independent sample and epigenetic examination of extant data predicting tissue-specific functionality in the brain were also conducted. Genome-wide significant effects were observed at rs1555839 (p=4.03×10 This study provides support for a novel trait locus at chromosome 10q23.31 and proposes a potential gene-brain-behaviour relationship for targeted future functional analysis to understand underlying biological mechanisms for reading disability.
Sections du résumé
BACKGROUND
Rapid automatised naming (RAN) and rapid alternating stimulus (RAS) are reliable predictors of reading disability. The underlying biology of reading disability is poorly understood. However, the high correlation among RAN, RAS and reading could be attributable to shared genetic factors that contribute to common biological mechanisms.
OBJECTIVE
To identify shared genetic factors that contribute to RAN and RAS performance using a multivariate approach.
METHODS
We conducted a multivariate genome-wide association analysis of RAN Objects, RAN Letters and RAS Letters/Numbers in a sample of 1331 Hispanic American and African-American youth. Follow-up neuroimaging genetic analysis of cortical regions associated with reading ability in an independent sample and epigenetic examination of extant data predicting tissue-specific functionality in the brain were also conducted.
RESULTS
Genome-wide significant effects were observed at rs1555839 (p=4.03×10
CONCLUSION
This study provides support for a novel trait locus at chromosome 10q23.31 and proposes a potential gene-brain-behaviour relationship for targeted future functional analysis to understand underlying biological mechanisms for reading disability.
Identifiants
pubmed: 30995994
pii: jmedgenet-2018-105874
doi: 10.1136/jmedgenet-2018-105874
pmc: PMC6678051
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
557-566Subventions
Organisme : NICHD NIH HHS
ID : P50 HD027802
Pays : United States
Organisme : NICHD NIH HHS
ID : K99 HD094902
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007094
Pays : United States
Organisme : NIDA NIH HHS
ID : RC2 DA029475
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001863
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD007149
Pays : United States
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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