Phenotypic and Functional Differences between Human Herpesvirus 6- and Human Cytomegalovirus-Specific T Cells.
Adolescent
Adult
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Cytomegalovirus
/ physiology
Cytomegalovirus Infections
/ immunology
Herpesvirus 6, Human
/ physiology
Humans
Leukocytes, Mononuclear
/ immunology
Middle Aged
Paris
Phenotype
Roseolovirus Infections
/ immunology
T-Lymphocytes, Regulatory
Young Adult
HCMV
HHV-6
effector T cells
regulatory T cells
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
01 07 2019
01 07 2019
Historique:
received:
03
01
2019
accepted:
09
04
2019
pubmed:
19
4
2019
medline:
29
5
2020
entrez:
19
4
2019
Statut:
epublish
Résumé
Human herpesvirus 6 (HHV-6) infects >90% of the population and establishes a latent infection with asymptomatic episodes of reactivation. However, HHV-6 reactivation is associated with morbidity and sometimes mortality in immunocompromised patients. To date, control of the virus in healthy virus carriers and the failure to control it in patients with disease remain poorly understood. In particular, knowledge of HHV-6-specific T-cell responses is limited. Here, we characterized HHV-6A- and HHV-6B-specific CD4
Identifiants
pubmed: 30996090
pii: JVI.02321-18
doi: 10.1128/JVI.02321-18
pmc: PMC6580948
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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