Pregnane X Receptor Activation Triggers Rapid ATP Release in Primed Macrophages That Mediates NLRP3 Inflammasome Activation.
Adenosine Triphosphate
/ metabolism
Animals
Caspase 1
/ metabolism
Cell Line, Tumor
Connexins
/ metabolism
Enzyme Activation
/ drug effects
Humans
Inflammasomes
/ metabolism
Interleukin-1beta
/ metabolism
Kinetics
Ligands
Macrophages
/ drug effects
Mice
NLR Family, Pyrin Domain-Containing 3 Protein
/ metabolism
Nerve Tissue Proteins
/ metabolism
Pregnane X Receptor
/ agonists
Receptors, Purinergic P2X7
/ metabolism
src-Family Kinases
/ metabolism
Journal
The Journal of pharmacology and experimental therapeutics
ISSN: 1521-0103
Titre abrégé: J Pharmacol Exp Ther
Pays: United States
ID NLM: 0376362
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
05
12
2018
accepted:
08
04
2019
pubmed:
21
4
2019
medline:
24
12
2019
entrez:
21
4
2019
Statut:
ppublish
Résumé
The pregnane X receptor (PXR) is a ligand-activated nuclear receptor that acts as a xenobiotic sensor, responding to compounds of foreign origin, including pharmaceutical compounds, environmental contaminants, and natural products, to induce transcriptional events that regulate drug detoxification and efflux pathways. As such, the PXR is thought to play a key role in protecting the host from xenobiotic exposure. More recently, the PXR has been reported to regulate the expression of innate immune receptors in the intestine and modulate inflammasome activation in the vasculature. In the current study, we report that activation of the PXR in primed macrophages triggers caspase-1 activation and interleukin-1
Identifiants
pubmed: 31004077
pii: jpet.118.255679
doi: 10.1124/jpet.118.255679
pmc: PMC6542184
doi:
Substances chimiques
Connexins
0
Inflammasomes
0
Interleukin-1beta
0
Ligands
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
Nerve Tissue Proteins
0
Panx1 protein, mouse
0
Pregnane X Receptor
0
Receptors, Purinergic P2X7
0
Adenosine Triphosphate
8L70Q75FXE
src-Family Kinases
EC 2.7.10.2
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
44-53Subventions
Organisme : NIEHS NIH HHS
ID : R01 ES030197
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM111381
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA161879
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025708
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA222469
Pays : United States
Informations de copyright
Copyright © 2019 by The Author(s).
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