Strategies that improve renal medullary oxygenation during experimental cardiopulmonary bypass may mitigate postoperative acute kidney injury.
Acute Kidney Injury
/ etiology
Animals
Arterial Pressure
/ drug effects
Cardiopulmonary Bypass
/ adverse effects
Cell Hypoxia
/ drug effects
Disease Models, Animal
Female
Humans
Kidney Medulla
/ blood supply
Metaraminol
/ administration & dosage
Oxygen
/ metabolism
Postoperative Complications
/ etiology
Renal Circulation
/ drug effects
Sheep
Vasoconstrictor Agents
/ administration & dosage
acute kidney injury
cardiac surgery
hypoxia
renal circulation
renal medulla
Journal
Kidney international
ISSN: 1523-1755
Titre abrégé: Kidney Int
Pays: United States
ID NLM: 0323470
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
21
11
2018
revised:
23
01
2019
accepted:
24
01
2019
pubmed:
22
4
2019
medline:
22
9
2020
entrez:
22
4
2019
Statut:
ppublish
Résumé
Renal medullary hypoxia may contribute to cardiac surgery-associated acute kidney injury (AKI). However, the effects of cardiopulmonary bypass (CPB) on medullary oxygenation are poorly understood. Here we tested whether CPB causes medullary hypoxia and whether medullary oxygenation during CPB can be improved by increasing pump flow or mean arterial pressure (MAP). Twelve sheep were instrumented to measure whole kidney, medullary, and cortical blood flow and oxygenation. Five days later, under isoflurane anesthesia, CPB was initiated at a pump flow of 80 mL kg
Identifiants
pubmed: 31005272
pii: S0085-2538(19)30175-9
doi: 10.1016/j.kint.2019.01.032
pii:
doi:
Substances chimiques
Vasoconstrictor Agents
0
Metaraminol
818U2PZ2EH
Oxygen
S88TT14065
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1338-1346Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2019 International Society of Nephrology. Published by Elsevier Inc. All rights reserved.