Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations.
Chronic enteropathy associated with SLCO2A1 gene
Chronic nonspecific multiple ulcers of the small intestine
Crohn’s disease
Prostaglandin E major urinary metabolites
Small intestine
Journal
World journal of gastroenterology
ISSN: 2219-2840
Titre abrégé: World J Gastroenterol
Pays: United States
ID NLM: 100883448
Informations de publication
Date de publication:
14 Apr 2019
14 Apr 2019
Historique:
received:
03
02
2019
revised:
27
02
2019
accepted:
11
03
2019
entrez:
24
4
2019
pubmed:
24
4
2019
medline:
27
8
2019
Statut:
ppublish
Résumé
We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with To examine whether prostaglandin E major urinary metabolites (PGE-MUM) can serve as a biomarker to distinguish CEAS from CD. This was a transactional study of 20 patients with CEAS and 98 patients with CD. CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of Twenty Japanese patients with CEAS and 98 patients with CD were enrolled. PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD (median 102.7 PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD.
Sections du résumé
BACKGROUND
BACKGROUND
We recently reported on a hereditary enteropathy associated with a gene encoding a prostaglandin transporter and referred to as chronic enteropathy associated with
AIM
OBJECTIVE
To examine whether prostaglandin E major urinary metabolites (PGE-MUM) can serve as a biomarker to distinguish CEAS from CD.
METHODS
METHODS
This was a transactional study of 20 patients with CEAS and 98 patients with CD. CEAS was diagnosed by the confirmation of homozygous or compound heterozygous mutation of
RESULTS
RESULTS
Twenty Japanese patients with CEAS and 98 patients with CD were enrolled. PGE-MUM concentration in patients with CEAS was significantly higher than that in patients with CD (median 102.7
CONCLUSION
CONCLUSIONS
PGE-MUM measurement is a convenient, non-invasive and useful test for the distinction of CEAS from CD.
Identifiants
pubmed: 31011259
doi: 10.3748/wjg.v25.i14.1753
pmc: PMC6465938
doi:
Substances chimiques
Organic Anion Transporters
0
Prostaglandins E
0
Prostanoic Acids
0
SLCO2A1 protein, human
0
11 alpha-hydroxy-9,15-dioxo-2,3,4,5,20-pentanor-19-carboxyprostanoic acid
24769-56-0
Types de publication
Journal Article
Observational Study
Langues
eng
Pagination
1753-1763Déclaration de conflit d'intérêts
Conflict-of-interest statement: All authors declare no conflicts-of-interest related to this article.
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