The Impact of Anthelmintic Treatment on Human Gut Microbiota Based on Cross-Sectional and Pre- and Postdeworming Comparisons in Western Kenya.
Adolescent
Adult
Aged
Aged, 80 and over
Anthelmintics
/ administration & dosage
Ascariasis
/ drug therapy
Bacteria
/ classification
Child
Child, Preschool
DNA, Bacterial
/ chemistry
DNA, Ribosomal
/ chemistry
Feces
/ microbiology
Gastrointestinal Microbiome
/ drug effects
Humans
Kenya
Metagenomics
Microbiota
/ drug effects
Middle Aged
Necatoriasis
/ drug therapy
RNA, Ribosomal, 16S
/ genetics
Real-Time Polymerase Chain Reaction
Rural Population
Sequence Analysis, DNA
Young Adult
16S RNA
epidemiology
helminths
hookworm
microbial communities
microbial ecology
microbiota
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
23 04 2019
23 04 2019
Historique:
entrez:
25
4
2019
pubmed:
25
4
2019
medline:
21
6
2019
Statut:
epublish
Résumé
Murine studies suggest that the presence of some species of intestinal helminths is associated with changes in host microbiota composition and diversity. However, studies in humans have produced varied conclusions, and the impact appears to vary widely depending on the helminth species present. To demonstrate how molecular approaches to the human gut microbiome can provide insights into the complex interplay among disparate organisms, DNA was extracted from cryopreserved stools collected from residents of 5 rural Kenyan villages prior to and 3 weeks and 3 months following albendazole (ALB) therapy. Samples were analyzed by quantitative PCR (qPCR) for the presence of 8 species of intestinal parasites and by MiSeq 16S rRNA gene sequencing. Based on pretreatment results, the presence of neither
Identifiants
pubmed: 31015324
pii: mBio.00519-19
doi: 10.1128/mBio.00519-19
pmc: PMC6479000
pii:
doi:
Substances chimiques
Anthelmintics
0
DNA, Bacterial
0
DNA, Ribosomal
0
RNA, Ribosomal, 16S
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : MR/R015600/1
Pays : United Kingdom
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