Metabolomics Profiling of Visceral Adipose Tissue: Results From MESA and the NEO Study.

Aged Aged, 80 and over Amino Acids / blood Amino Acids, Branched-Chain / blood Cholesterol, HDL / blood Cholesterol, LDL / blood Female Gluconeogenesis Glutamine / blood Glycolysis Humans Intra-Abdominal Fat / diagnostic imaging Lactic Acid / blood Linear Models Magnetic Resonance Imaging Male Metabolic Networks and Pathways Metabolomics Middle Aged Organ Size Proton Magnetic Resonance Spectroscopy Tomography, X-Ray Computed Triglycerides / blood
adipose tissue cohort metabolite metabolomics obesity visceral adipose tissue

Journal

Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524

Informations de publication

Date de publication:
07 05 2019
Historique:
entrez: 25 4 2019
pubmed: 25 4 2019
medline: 18 8 2020
Statut: ppublish

Résumé

Background Identifying associations between serum metabolites and visceral adipose tissue ( VAT ) could provide novel biomarkers of VAT and insights into the pathogenesis of obesity-related diseases. We aimed to discover and replicate metabolites reflecting pathways related to VAT . Methods and Results Associations between fasting serum metabolites and VAT area (by computed tomography or magnetic resonance imaging) were assessed with cross-sectional linear regression of individual-level data from participants in MESA (Multi-Ethnic Study of Atherosclerosis; discovery, N=1103) and the NEO (Netherlands Epidemiology of Obesity) study (replication, N=2537). Untargeted

Identifiants

DOI: 10.1161/JAHA.118.010810 PMID: 31017036 PMC: PMC6512086
pubmed: 31017036
doi: 10.1161/JAHA.118.010810
pmc: PMC6512086
doi:

Substances chimiques

Amino Acids 0
Amino Acids, Branched-Chain 0
Cholesterol, HDL 0
Cholesterol, LDL 0
Triglycerides 0
Glutamine 0RH81L854J
Lactic Acid 33X04XA5AT

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e010810

Subventions

Organisme : NIH HHS
ID : HHSN263201500003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL088451
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95161
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133932
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95168
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001420
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95165
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95167
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95159
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95163
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000040
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95160
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003C
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95169
Pays : United States
Organisme : NIDDK NIH HHS
ID : K23 DK106520
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95162
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95164
Pays : United States
Organisme : NHLBI NIH HHS
ID : HHSN268201500003I
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL111362
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001079
Pays : United States
Organisme : NHLBI NIH HHS
ID : N01HC95166
Pays : United States

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Auteurs

Ian J Neeland (IJ)

1 Division of Cardiology Department of Internal Medicine University of Texas Southwestern Medical Center Dallas TX.

Sebastiaan C Boone (SC)

2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.

Dennis O Mook-Kanamori (DO)

2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.
3 Department of Public Health and Primary Care Leiden University Medical Center Leiden the Netherlands.

Colby Ayers (C)

4 Department of Clinical Sciences University of Texas Southwestern Medical Center Dallas TX.

Roelof A J Smit (RAJ)

2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.

Ioanna Tzoulaki (I)

5 Department of Epidemiology and Biostatistics Imperial College London London United Kingdom.

Ibrahim Karaman (I)

5 Department of Epidemiology and Biostatistics Imperial College London London United Kingdom.

Claire Boulange (C)

6 Metabometrix Ltd Imperial College London London United Kingdom.

Dhananjay Vaidya (D)

7 Department of Medicine Johns Hopkins University Baltimore MD.

Naresh Punjabi (N)

7 Department of Medicine Johns Hopkins University Baltimore MD.

Matthew Allison (M)

8 Department of Family Medicine and Public Health University of California San Diego La Jolla CA.

David M Herrington (DM)

9 Department of Medicine Wake Forest University Winston Salem NC.

J Wouter Jukema (JW)

10 Department of Cardiology Leiden University Medical Center Leiden the Netherlands.

Frits R Rosendaal (FR)

2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.

Hildo J Lamb (HJ)

11 Department of Radiology Leiden University Medical Center Leiden the Netherlands.

Ko Willems van Dijk (KW)

12 Department of Human Genetics Leiden University Medical Center Leiden the Netherlands.
13 Department of Internal Medicine Leiden University Medical Center Leiden the Netherlands.
14 Einthoven Laboratory for Experimental Vascular Medicine Leiden University Medical Center Leiden the Netherlands.

Philip Greenland (P)

15 Department of Preventive Medicine Northwestern University Chicago IL.

Renée de Mutsert (R)

2 Department of Clinical Epidemiology Leiden University Medical Center Leiden the Netherlands.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés à chaine ramifiée › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines HDL › Cholestérol HDL › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines LDL › Cholestérol LDL › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Métabolisme › Métabolisme glucidique › Néoglucogenèse › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Acides aminés neutres › Glutamine › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Glycolyse › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Tissus › Tissu conjonctif › Tissu adipeux › Tissu adipeux blanc › Graisse abdominale › Graisse intra-abdominale › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Hydroxyacides › Lactates › Acide lactique › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles linéaires › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Métabolisme › Voies et réseaux métaboliques › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Disciplines des sciences naturelles › Chimie › Biochimie › Métabolomique › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Croissance › Taille d'organe › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Spectroscopie par résonance magnétique du proton › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Metabolomics Profiling of Visceral Adipose...
questionsmedicales.fr › Lipides › Glycérides › Triglycéride › Metabolomics Profiling of Visceral Adipose...