Optogenetic dissection of basolateral amygdala contributions to intertemporal choice in young and aged rats.
aging
basolateral amygdala
decision making
delay discounting
impulsive choice
intertemporal choice
neuroscience
rat
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
24 04 2019
24 04 2019
Historique:
received:
18
02
2019
accepted:
23
04
2019
pubmed:
25
4
2019
medline:
12
3
2020
entrez:
25
4
2019
Statut:
epublish
Résumé
Across species, aging is associated with an increased ability to choose delayed over immediate gratification. These experiments used young and aged rats to test the role of the basolateral amygdala (BLA) in intertemporal decision making. An optogenetic approach was used to inactivate the BLA in young and aged rats at discrete time points during choices between levers that yielded a small, immediate vs. a large, delayed food reward. BLA inactivation just prior to decisions attenuated impulsive choice in both young and aged rats. In contrast, inactivation during receipt of the small, immediate reward increased impulsive choice in young rats but had no effect in aged rats. BLA inactivation during the delay or intertrial interval had no effect at either age. These data demonstrate that the BLA plays multiple, temporally distinct roles during intertemporal choice, and show that the contribution of BLA to choice behavior changes across the lifespan.
Identifiants
pubmed: 31017572
doi: 10.7554/eLife.46174
pii: 46174
pmc: PMC6530979
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : RF1 AG060778
Pays : United States
Organisme : NIH HHS
ID : K99DA041493
Pays : United States
Organisme : NIH HHS
ID : RF1AG060778
Pays : United States
Organisme : NIH HHS
ID : R01AG029421
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG029421
Pays : United States
Organisme : NIDA NIH HHS
ID : K99 DA041493
Pays : United States
Informations de copyright
© 2019, Hernandez et al.
Déclaration de conflit d'intérêts
CH, CO, CL, AW, TT, MB, TS, SH, CF, BS, JB No competing interests declared
Références
Psychopharmacology (Berl). 1996 Nov;128(2):161-70
pubmed: 8956377
Alzheimers Dement (Amst). 2017 Mar 14;6:222-231
pubmed: 28393099
J Comp Neurol. 2009 Feb 20;512(6):717-25
pubmed: 19065620
PLoS One. 2012;7(8):e43647
pubmed: 22916287
Neurobiol Aging. 2017 Dec;60:141-152
pubmed: 28946018
Behav Processes. 2011 Jul;87(3):253-9
pubmed: 21550384
eNeuro. 2017 Oct 6;4(5):
pubmed: 29034315
Neuron. 2016 Jun 1;90(5):927-39
pubmed: 27253447
Neurobiol Learn Mem. 2017 Mar;139:89-97
pubmed: 28065715
Ann N Y Acad Sci. 2011 Oct;1235:18-29
pubmed: 22023565
J Neurosci. 2009 Apr 22;29(16):5251-9
pubmed: 19386921
Neuropsychopharmacology. 2014 Mar;39(4):955-62
pubmed: 24145852
Personal Disord. 2015 Apr;6(2):182-98
pubmed: 25867841
Nat Neurosci. 2017 Jun;20(6):824-835
pubmed: 28436980
Behav Processes. 1999 May 3;46(1):89-96
pubmed: 24925501
Psychol Aging. 2011 Jun;26(2):274-284
pubmed: 21534688
Eur J Neurosci. 2009 Aug;30(3):472-84
pubmed: 19656177
Front Neurosci. 2011 Nov 16;5:126
pubmed: 22110424
J Neurosci. 2014 Jul 23;34(30):9905-16
pubmed: 25057193
Neurobiol Aging. 2010 May;31(5):853-62
pubmed: 18657883
J Int Neuropsychol Soc. 2012 Jul;18(4):773-80
pubmed: 22591835
Neurobiol Aging. 2009 Jan;30(1):137-46
pubmed: 17570563
Psychol Aging. 1996 Mar;11(1):79-84
pubmed: 8726373
Proc Natl Acad Sci U S A. 2012 Nov 13;109(46):18950-5
pubmed: 23112182
Behav Neurosci. 2009 Dec;123(6):1185-96
pubmed: 20001103
Psychol Sci. 2008 Sep;19(9):904-11
pubmed: 18947356
PLoS One. 2012;7(5):e36953
pubmed: 22655032
Gerontology. 2014;60(1):3-9
pubmed: 24080587
J Neurosci. 2004 May 19;24(20):4718-22
pubmed: 15152031
Cell Rep. 2017 Nov 7;21(6):1426-1433
pubmed: 29117549
J Neurosci Res. 2016 Jun;94(6):548-67
pubmed: 26586374
Trends Neurosci. 2013 Feb;36(2):110-20
pubmed: 23333342
Ann N Y Acad Sci. 2007 Dec;1121:480-98
pubmed: 17872394
Neuropharmacology. 2018 Sep 1;139:205-216
pubmed: 30009836
Psychol Sci. 2017 Apr;28(4):504-518
pubmed: 28406375
Psychopharmacology (Berl). 2014 Apr;231(8):1615-26
pubmed: 24408208
J Neurosci. 1996 Aug 15;16(16):5256-65
pubmed: 8756453
J Cogn Neurosci. 2012 Jan;24(1):196-211
pubmed: 21916564
J Neurosci. 2000 Jun 1;20(11):4311-9
pubmed: 10818166
Brain Res. 2015 Jul 1;1612:48-58
pubmed: 25305568
Nat Rev Neurosci. 2008 Jul;9(7):545-56
pubmed: 18545266
J Neurosci. 2013 Jun 12;33(24):9905-12
pubmed: 23761885
eNeuro. 2018 Dec 10;5(6):
pubmed: 30627636
J Neurosci. 2014 Nov 19;34(47):15648-57
pubmed: 25411493
Psychopharmacology (Berl). 2010 Jul;211(1):87-98
pubmed: 20428999
J Neurosci. 2012 Sep 19;32(38):13137-44
pubmed: 22993430
J Neurosci. 2013 May 15;33(20):8753-63
pubmed: 23678118
Biol Psychiatry. 2012 Jun 15;71(12):1053-60
pubmed: 22169096
Ann N Y Acad Sci. 2003 Apr;985:233-50
pubmed: 12724162
J Neurosci. 2011 Nov 30;31(48):17460-70
pubmed: 22131407
Nat Rev Neurosci. 2015 May;16(5):278-89
pubmed: 25873038
Neuron. 2008 Aug 28;59(4):648-61
pubmed: 18760700
Brain Res. 2014 Jul 29;1574:26-36
pubmed: 24928616
Neuropharmacology. 2014 Jan;76 Pt B:518-27
pubmed: 23806805
Neurosci Biobehav Rev. 2015 Oct;57:271-83
pubmed: 26341938
J Neurosci. 2017 Nov 29;37(48):11537-11548
pubmed: 29079687
Neurobiol Learn Mem. 2016 Sep;133:233-256
pubmed: 27427327
J Neurosci. 1999 Mar 1;19(5):1876-84
pubmed: 10024371
Psychol Aging. 2012 Dec;27(4):801-16
pubmed: 23066800
Exp Clin Psychopharmacol. 2009 Feb;17(1):51-61
pubmed: 19186934
Biol Psychiatry. 2015 Nov 1;78(9):606-14
pubmed: 25641636
Eur J Neurosci. 2010 Nov;32(10):1735-43
pubmed: 21044174
J Neurosci. 1997 Aug 1;17(15):6011-20
pubmed: 9221797
Neurobiol Aging. 2002 Mar-Apr;23(2):319-24
pubmed: 11804717
Cogn Affect Behav Neurosci. 2008 Dec;8(4):375-89
pubmed: 19033236
Neurobiol Learn Mem. 2015 Jan;117:60-70
pubmed: 24642448
Trends Cogn Sci. 2011 May;15(5):227-39
pubmed: 21497544
Neurosci Biobehav Rev. 2015 Nov;58:147-67
pubmed: 26072028
J Neurosci. 2013 Feb 27;33(9):4105-9
pubmed: 23447618
Nat Neurosci. 1998 Jun;1(2):155-9
pubmed: 10195132
Clin Psychol Rev. 2016 Feb;43:162-74
pubmed: 26602954
Brain Res. 1991 Nov 8;564(1):97-101
pubmed: 1777825
J Neurophysiol. 2013 Jul;110(1):221-9
pubmed: 23657281
Nat Rev Neurosci. 2002 Jul;3(7):563-73
pubmed: 12094212
Eur J Neurosci. 2017 Feb;45(3):388-397
pubmed: 27977047
Eur J Neurosci. 2013 Feb;37(4):640-7
pubmed: 23190048
J Neurosci. 2015 Jan 28;35(4):1368-79
pubmed: 25632115
Neurobiol Aging. 2015 Nov;36(11):3067-3078
pubmed: 26281759
Eur Neuropsychopharmacol. 2017 Sep;27(9):900-912
pubmed: 28647452
Curr Biol. 2016 Nov 21;26(22):3004-3013
pubmed: 27773572
J Hirnforsch. 1991;32(2):231-8
pubmed: 1791303