Serotonin transporter-ibogaine complexes illuminate mechanisms of inhibition and transport.
Binding Sites
/ drug effects
Binding, Competitive
Biological Transport
/ drug effects
Cryoelectron Microscopy
Hallucinogens
/ chemistry
Humans
Ibogaine
/ chemistry
Models, Molecular
Protein Conformation
/ drug effects
Serotonin
/ metabolism
Serotonin Plasma Membrane Transport Proteins
/ chemistry
Selective Serotonin Reuptake Inhibitors
/ chemistry
Structure-Activity Relationship
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
06
07
2018
accepted:
25
03
2019
pubmed:
26
4
2019
medline:
3
8
2019
entrez:
26
4
2019
Statut:
ppublish
Résumé
The serotonin transporter (SERT) regulates neurotransmitter homeostasis through the sodium- and chloride-dependent recycling of serotonin into presynaptic neurons
Identifiants
pubmed: 31019304
doi: 10.1038/s41586-019-1135-1
pii: 10.1038/s41586-019-1135-1
pmc: PMC6750207
mid: NIHMS1046285
doi:
Substances chimiques
Hallucinogens
0
Serotonin Plasma Membrane Transport Proteins
0
Serotonin Uptake Inhibitors
0
Serotonin
333DO1RDJY
Ibogaine
3S814I130U
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Pagination
141-145Subventions
Organisme : NIMH NIH HHS
ID : R01 MH070039
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM123455
Pays : United States
Organisme : NIGMS NIH HHS
ID : U54 GM087519
Pays : United States
Organisme : NIMH NIH HHS
ID : R37 MH070039
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NIH HHS
ID : 5R37MH070039
Pays : United States
Organisme : NIGMS NIH HHS
ID : P41 GM104601
Pays : United States
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