Study of the in vitro metabolic profile of a new α

Adrenergic alpha-2 Receptor Agonists / metabolism Analgesics / metabolism Animals Chronic Pain / drug therapy Drug Evaluation, Preclinical Humans Imidazolidines / metabolism Magnetic Resonance Spectroscopy Microsomes, Liver / metabolism Oxidation-Reduction Rats Tandem Mass Spectrometry
Cytochrome P450 In vitro metabolism LC–MS Liver microsome Metabolite identification α(2)-Adrenergic agonist

Journal

Journal of pharmaceutical and biomedical analysis
ISSN: 1873-264X
Titre abrégé: J Pharm Biomed Anal
Pays: England
ID NLM: 8309336

Informations de publication

Date de publication:
05 Aug 2019
Historique:
received: 15 01 2019
revised: 26 03 2019
accepted: 30 03 2019
pubmed: 29 4 2019
medline: 30 11 2019
entrez: 29 4 2019
Statut: ppublish

Résumé

A potent synthetic α

Identifiants

DOI: 10.1016/j.jpba.2019.03.067 PMID: 31029802
pubmed: 31029802
pii: S0731-7085(19)30124-4
doi: 10.1016/j.jpba.2019.03.067
pii:
doi:

Substances chimiques

3-(2-chloro-6-fluorobenzyl)-imidazolidine-2,4-dione 0
Adrenergic alpha-2 Receptor Agonists 0
Analgesics 0
Imidazolidines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

67-77

Informations de copyright

Copyright © 2019. Published by Elsevier B.V.

Auteurs

Josiane de O Cardoso (J)

Núcleo de Pesquisa em Cromatografia (Separare), Department of Chemistry, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil.

Bianca F da Silva (BF)

Núcleo de Pesquisa em Cromatografia (Separare), Department of Chemistry, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil.

Tiago Venâncio (T)

Núcleo de Pesquisa em Cromatografia (Separare), Department of Chemistry, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil.

Marina G da Rocha Pitta (MG)

Núcleo de Pesquisa em Inovação Terapêutica (NUPIT), Federal University of Pernambuco, Recife, PE, 50670-901, Brazil.

Ivan da R Pitta (I)

Núcleo de Pesquisa em Inovação Terapêutica (NUPIT), Federal University of Pernambuco, Recife, PE, 50670-901, Brazil.

Rosângela G Peccinini (RG)

College of Pharmaceutical Sciences, São Paulo State University, Araraquara, SP, 14801-902, Brazil.

Regina V Oliveira (RV)

Núcleo de Pesquisa em Cromatografia (Separare), Department of Chemistry, Federal University of São Carlos, São Carlos, SP, 13565-905, Brazil. Electronic address: oliveirarv@ufscar.br.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents adrénergiques › Agonistes adrénergiques › Agonistes alpha-adrénergiques › Agonistes des récepteurs alpha-2 adrénergiques › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Analgésiques › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Eucaryotes › Animaux › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur chronique › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Techniques d'investigation › Évaluation préclinique de médicament › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Imidazolidines › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Cellules › Structures cellulaires › Fractions subcellulaires › Microsomes › Microsomes du foie › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Métabolisme › Métabolisme énergétique › Oxydoréduction › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Study of the in vitro metabolic profile of a new α
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Spectrométrie de masse › Spectrométrie de masse en tandem › Study of the in vitro metabolic profile of a new α