Disentangling Genetic and Environmental Effects on the Proteotypes of Individuals.
Journal
Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066
Informations de publication
Date de publication:
16 05 2019
16 05 2019
Historique:
received:
13
09
2018
revised:
18
01
2019
accepted:
05
03
2019
pubmed:
30
4
2019
medline:
26
2
2020
entrez:
30
4
2019
Statut:
ppublish
Résumé
Proteotypes, like genotypes, have been found to vary between individuals in several studies, but consistent molecular functional traits across studies remain to be quantified. In a meta-analysis of 11 proteomics datasets from humans and mice, we use co-variation of proteins in known functional modules across datasets and individuals to obtain a consensus landscape of proteotype variation. We find that individuals differ considerably in both protein complex abundances and stoichiometry. We disentangle genetic and environmental factors impacting these metrics, with genetic sex and specific diets together explaining 13.5% and 11.6% of the observed variation of complex abundance and stoichiometry, respectively. Sex-specific differences, for example, include various proteins and complexes, where the respective genes are not located on sex-specific chromosomes. Diet-specific differences, added to the individual genetic backgrounds, might become a starting point for personalized proteotype modulation toward desired features.
Identifiants
pubmed: 31031010
pii: S0092-8674(19)30277-6
doi: 10.1016/j.cell.2019.03.015
pmc: PMC6988111
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1308-1318.e10Informations de copyright
Copyright © 2019 European Molecular Biology Laboratory. Published by Elsevier Inc. All rights reserved.
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