Therapeutic options after surgical failure in Cushing's disease: A critical review.
ACTH
adrenal steroidogenesis inhibitor
bilateral adrenalectomy
hypercortisolism
pituitary radiation
transsphenoidal surgery
Journal
Best practice & research. Clinical endocrinology & metabolism
ISSN: 1878-1594
Titre abrégé: Best Pract Res Clin Endocrinol Metab
Pays: Netherlands
ID NLM: 101120682
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
pubmed:
1
5
2019
medline:
15
1
2020
entrez:
1
5
2019
Statut:
ppublish
Résumé
Cushing's disease (CD) is the most common etiology of Cushing's syndrome (CD) due to corticotroph pituitary adenoma, which are in most cases small (80-90% microadenomas) and in about 40% cannot be visualized on imaging of the sella. First-line treatment for CD is transsphenoidal surgery (TSS) with the aim of complete adenoma removal and preservation of pituitary gland function. As complete adenoma resection is not always possible, surgical failure is a common problem. This can be the case either due to persistent hypercortisolism after first TSS or recurrence of hypercortisolism after initially achieving remission. For these scenarios exist several therapeutic options with their inherent characteristics, which will be covered by this review.
Identifiants
pubmed: 31036383
pii: S1521-690X(19)30013-2
doi: 10.1016/j.beem.2019.04.004
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
101270Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.