EZH2 Is Overexpressed in
Animals
Antineoplastic Agents
/ therapeutic use
BRCA1 Protein
/ genetics
BRCA2 Protein
/ genetics
Biomarkers, Tumor
/ genetics
Breast Neoplasms
/ drug therapy
Enhancer of Zeste Homolog 2 Protein
/ genetics
Female
Humans
Mammary Neoplasms, Animal
/ drug therapy
Mice
Mice, Knockout
Platinum
/ therapeutic use
Survival Rate
Treatment Outcome
Journal
Clinical cancer research : an official journal of the American Association for Cancer Research
ISSN: 1557-3265
Titre abrégé: Clin Cancer Res
Pays: United States
ID NLM: 9502500
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
received:
10
12
2018
revised:
25
02
2019
accepted:
24
04
2019
pubmed:
1
5
2019
medline:
23
9
2020
entrez:
1
5
2019
Statut:
ppublish
Résumé
BRCA1-deficient breast cancers carry a specific DNA copy-number signature (" EZH2 expression was analyzed in 497 breast cancers using IHC or RNA sequencing. We classified 370 tumors by copy-number profiles as The highest EZH2 expression was found in BRCA1-associated tumors harboring a Our findings demonstrate that EZH2 is expressed at significantly higher levels in
Identifiants
pubmed: 31036541
pii: 1078-0432.CCR-18-4024
doi: 10.1158/1078-0432.CCR-18-4024
doi:
Substances chimiques
Antineoplastic Agents
0
BRCA1 Protein
0
BRCA1 protein, human
0
BRCA2 Protein
0
BRCA2 protein, human
0
Biomarkers, Tumor
0
Platinum
49DFR088MY
EZH2 protein, human
EC 2.1.1.43
Enhancer of Zeste Homolog 2 Protein
EC 2.1.1.43
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4351-4362Informations de copyright
©2019 American Association for Cancer Research.