Insight into microtubule nucleation from tubulin-capping proteins.
CopN
artificial binding proteins
cytoskeleton
microtubule nucleation
structural biology
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
14 05 2019
14 05 2019
Historique:
pubmed:
1
5
2019
medline:
27
3
2020
entrez:
1
5
2019
Statut:
ppublish
Résumé
Nucleation is one of the least understood steps of microtubule dynamics. It is a kinetically unfavorable process that is templated in the cell by the γ-tubulin ring complex or by preexisting microtubules; it also occurs in vitro from pure tubulin. Here we study the nucleation inhibition potency of natural or artificial proteins in connection with their binding mode to the longitudinal surface of α- or β-tubulin. The structure of tubulin-bound CopN, a
Identifiants
pubmed: 31036638
pii: 1813559116
doi: 10.1073/pnas.1813559116
pmc: PMC6525497
doi:
Substances chimiques
Bacterial Proteins
0
Tubulin
0
Banques de données
PDB
['6GX7', '6GVM', '6GVN']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
9859-9864Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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