Host-pathogen coevolution increases genetic variation in susceptibility to infection.
Alleles
Animals
Chromosome Mapping
Disease Resistance
/ genetics
Disease Susceptibility
Drosophila melanogaster
/ genetics
Female
Genes, Insect
Genetic Variation
Host-Pathogen Interactions
/ genetics
Infections
/ genetics
Male
Polymorphism, Genetic
Rhabdoviridae
/ physiology
Rhabdoviridae Infections
/ virology
Selection, Genetic
Species Specificity
Viral Load
D. melanogaster
Drosophila
coevolution
evolutionary biology
sigma virus
virus
viruses
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
30 04 2019
30 04 2019
Historique:
received:
03
03
2019
accepted:
07
04
2019
entrez:
1
5
2019
pubmed:
1
5
2019
medline:
5
3
2020
Statut:
epublish
Résumé
It is common to find considerable genetic variation in susceptibility to infection in natural populations. We have investigated whether natural selection increases this variation by testing whether host populations show more genetic variation in susceptibility to pathogens that they naturally encounter than novel pathogens. In a large cross-infection experiment involving four species of
Identifiants
pubmed: 31038124
doi: 10.7554/eLife.46440
pii: 46440
pmc: PMC6491035
doi:
pii:
Banques de données
figshare
['10.6084/m9.figshare.6743354', '10.6084/m9.figshare.6743339', '10.6084/m9.figshare.7195751']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI139154
Pays : United States
Organisme : NIGMS NIH HHS
ID : R00 GM114714
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Informations de copyright
© 2019, Duxbury et al.
Déclaration de conflit d'intérêts
ED, JD, DM, YT, IT, SS, LT, AK, IL, LL, RU, FJ, BL No competing interests declared
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