Inflammation-mediated deacetylation of the ribonuclease 1 promoter
Benzamides
/ pharmacology
Cells, Cultured
Chromatin
/ genetics
Chromatin Immunoprecipitation
Gene Knockdown Techniques
Histone Deacetylase 1
/ antagonists & inhibitors
Histone Deacetylase 2
/ antagonists & inhibitors
Histone Deacetylase Inhibitors
/ pharmacology
Human Umbilical Vein Endothelial Cells
/ drug effects
Humans
Inflammation Mediators
/ metabolism
Promoter Regions, Genetic
Pyridines
/ pharmacology
RNA, Messenger
/ genetics
Ribonuclease, Pancreatic
/ genetics
Tumor Necrosis Factor-alpha
/ metabolism
MS275
TNF-α
chromatin immunoprecipitation
histone acetylation
vascular homeostasis
Journal
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
ISSN: 1530-6860
Titre abrégé: FASEB J
Pays: United States
ID NLM: 8804484
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
pubmed:
1
5
2019
medline:
2
6
2020
entrez:
1
5
2019
Statut:
ppublish
Résumé
Ribonuclease 1 (RNase1) is a circulating extracellular endonuclease that regulates the vascular homeostasis of extracellular RNA and acts as a vessel- and tissue-protective enzyme. Upon long-term inflammation, high amounts of proinflammatory cytokines affect endothelial cell (EC) function by down-regulation of RNase1. Here, we investigated the transcriptional regulation of RNase1 upon inflammation in HUVECs. TNF-α or IL-1β stimulation reduced the expression of RNase1 relative to the acetylation state of histone 3 at lysine 27 and histone 4 of the
Identifiants
pubmed: 31039328
doi: 10.1096/fj.201900451R
doi:
Substances chimiques
Benzamides
0
Chromatin
0
Histone Deacetylase Inhibitors
0
Inflammation Mediators
0
Pyridines
0
RNA, Messenger
0
Tumor Necrosis Factor-alpha
0
entinostat
1ZNY4FKK9H
Ribonuclease, Pancreatic
EC 3.1.27.5
HDAC1 protein, human
EC 3.5.1.98
HDAC2 protein, human
EC 3.5.1.98
Histone Deacetylase 1
EC 3.5.1.98
Histone Deacetylase 2
EC 3.5.1.98
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM