Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.
Alleles
Autoimmunity
/ genetics
Genotype
HEK293 Cells
Humans
Immune Tolerance
/ genetics
Immunity
/ genetics
Immunologic Deficiency Syndromes
/ genetics
Interleukin-2 Receptor beta Subunit
/ genetics
Killer Cells, Natural
/ metabolism
Lentivirus
/ metabolism
Mutation
/ genetics
Mutation, Missense
/ genetics
Phenotype
Phosphorylation
STAT3 Transcription Factor
/ metabolism
STAT5 Transcription Factor
/ metabolism
Signal Transduction
T-Lymphocytes
/ metabolism
Journal
The Journal of experimental medicine
ISSN: 1540-9538
Titre abrégé: J Exp Med
Pays: United States
ID NLM: 2985109R
Informations de publication
Date de publication:
03 06 2019
03 06 2019
Historique:
received:
13
12
2018
revised:
21
02
2019
accepted:
04
04
2019
pubmed:
2
5
2019
medline:
15
4
2020
entrez:
2
5
2019
Statut:
ppublish
Résumé
Interleukin-2, which conveys essential signals for immunity, operates through a heterotrimeric receptor. Here we identify human interleukin-2 receptor (IL-2R) β chain (
Identifiants
pubmed: 31040185
pii: jem.20182304
doi: 10.1084/jem.20182304
pmc: PMC6547869
doi:
Substances chimiques
IL2RB protein, human
0
Interleukin-2 Receptor beta Subunit
0
STAT3 Transcription Factor
0
STAT5 Transcription Factor
0
Banques de données
PDB
['2B5I', '5M5E']
Types de publication
Journal Article
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1311-1327Subventions
Organisme : Wellcome Trust
ID : 101908/Z/13/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 207556/Z/17/Z
Pays : United Kingdom
Organisme : Department of Health
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 083650/Z/07/Z
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 099966/Z/12/Z
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
This is a work of the U.S. Government and is not subject to copyright protection in the United States. Foreign copyrights may apply.
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