Yorgo Modis

Affiliations

Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, UK.

Publications (16)

MAVS polymers smaller than 80 nm induce mitochondrial membrane remodeling and interferon signaling.

The FEBS journal

Avec: Ming-Shih Hwang , Jérôme Boulanger , Jonathan D Howe , Anna Albecka , Mathias Pasche , Leila Mureşan , Yorgo Modis

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.

The Journal of experimental medicine

Avec: Zinan Zhang , Florian Gothe , Perrine Pennamen , John R James , David McDonald , Carlos P Mata , Yorgo Modis , Anas M Alazami , Meghan Acres , Wolfram Haller , Claire Bowen , Rainer Döffinger , Jan Sinclair , Shannon Brothers , Yu Zhang , Helen F Matthews , Sophie Naudion , Fanny Pelluard , Huda Alajlan , Yasuhiro Yamazaki , Luigi D Notarangelo , James E Thaventhiran , Karin R Engelhardt , Hamoud Al-Mousa , Sophie Hambleton , Caroline Rooryck , Kenneth G C Smith , Michael J Lenardo

Periphilin self-association underpins epigenetic silencing by the HUSH complex.

Nucleic acids research

Avec: Daniil M Prigozhin , Christopher H Douse , Laura E Farleigh , Anna Albecka , Iva A Tchasovnikarova , Richard T Timms , Shun-Ichiro Oda , Frank Adolf , Stefan M V Freund , Sarah Maslen , Paul J Lehner , Yorgo Modis

SARS-CoV-2 evolution during treatment of chronic infection.

Nature

Avec: Steven A Kemp , Dami A Collier , Rawlings P Datir , Isabella A T M Ferreira , Salma Gayed , Aminu Jahun , Myra Hosmillo , Chloe Rees-Spear , Petra Mlcochova , Ines Ushiro Lumb , David J Roberts , Anita Chandra , Nigel Temperton , Auteur inconnu , Auteur inconnu , Katherine Sharrocks , Elizabeth Blane , Yorgo Modis , Kendra E Leigh , John A G Briggs , Marit J van Gils , Kenneth G C Smith , John R Bradley , Chris Smith , Rainer Doffinger , Lourdes Ceron-Gutierrez , Gabriela Barcenas-Morales , David D Pollock , Richard A Goldstein , Anna Smielewska , Jordan P Skittrall , Theodore Gouliouris , Ian G Goodfellow , Effrossyni Gkrania-Klotsas , Christopher J R Illingworth , Laura E McCoy , Ravindra K Gupta

Equilibrium Binding Model for CpG DNA-Dependent Dimerization of Toll-like Receptor 9 Ectodomain.

Biochemistry

Avec: Stephanie Reikine , Stephen H McLaughlin , Yorgo Modis

Structure of KAP1 tripartite motif identifies molecular interfaces required for retroelement silencing.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Guido A Stoll , Shun-Ichiro Oda , Zheng-Shan Chong , Minmin Yu , Stephen H McLaughlin , Yorgo Modis

Imaging and visualizing SARS-CoV-2 in a new era for structural biology.

Interface focus

Avec: Kendra E Leigh , Yorgo Modis

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.

Cell

Avec: M Zaeem Cader , Rodrigo Pereira de Almeida Rodrigues , James A West , Gavin W Sewell , Muhammad N Md-Ibrahim , Stephanie Reikine , Giuseppe Sirago , Lukas W Unger , Ana Belén Iglesias-Romero , Katharina Ramshorn , Lea-Maxie Haag , Svetlana Saveljeva , Jana-Fabienne Ebel , Philip Rosenstiel , Nicole C Kaneider , James C Lee , Trevor D Lawley , Allan Bradley , Gordon Dougan , Yorgo Modis , Julian L Griffin , Arthur Kaser

MDA5 disease variant M854K prevents ATP-dependent structural discrimination of viral and cellular RNA.

Nature communications

Avec: Qin Yu , Alba Herrero Del Valle , Rahul Singh , Yorgo Modis

TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.

Nature communications

Avec: Christopher H Douse , Iva A Tchasovnikarova , Richard T Timms , Anna V Protasio , Marta Seczynska , Daniil M Prigozhin , Anna Albecka , Jane Wagstaff , James C Williamson , Stefan M V Freund , Paul J Lehner , Yorgo Modis

Cryo-electron tomography of NLRP3-activated ASC complexes reveals organelle co-localization.

Nature communications

Avec: Yangci Liu , Haoming Zhai , Helen Alemayehu , Jérôme Boulanger , Lee J Hopkins , Alicia C Borgeaud , Christina Heroven , Jonathan D Howe , Kendra E Leigh , Clare E Bryant , Yorgo Modis

Crystal structure and biochemical activity of the macrodomain from rubella virus p150.

Journal of virology

Avec: Guido A Stoll , Nikos Nikolopoulos , Haoming Zhai , Liao Zhang , Christopher H Douse , Yorgo Modis

A bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.

Science advances

Avec: Monique Merchant , Carlos P Mata , Yangci Liu , Haoming Zhai , Anna V Protasio , Yorgo Modis

The vaccinia chondroitin sulfate binding protein drives host membrane curvature to facilitate fusion.

EMBO reports

Avec: Laura Pokorny , Jemima J Burden , David Albrecht , Rebecca Bamford , Kendra E Leigh , Pooja Sridhar , Timothy J Knowles , Yorgo Modis , Jason Mercer

Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing.

The Journal of biological chemistry

Avec: Rahul Singh , Yuan Wu , Alba Herrero Del Valle , Kendra E Leigh , Sai Mong , Mark T K Cheng , Brian J Ferguson , Yorgo Modis

Structure and functional mapping of the KRAB-KAP1 repressor complex.

The EMBO journal

Avec: Guido A Stoll , Ninoslav Pandiloski , Christopher H Douse , Yorgo Modis

Réseau de co-auteurs

Kendra E Leigh 5 collaborations

Christopher H Douse 4 collaborations

Anna Albecka 3 collaborations

Guido A Stoll 3 collaborations

Haoming Zhai 3 collaborations

Jérôme Boulanger 2 collaborations

Jonathan D Howe 2 collaborations

Carlos P Mata 2 collaborations

Kenneth G C Smith 2 collaborations

Daniil M Prigozhin 2 collaborations

Iva A Tchasovnikarova 2 collaborations

Richard T Timms 2 collaborations

Shun-Ichiro Oda 2 collaborations

Stefan M V Freund 2 collaborations

Paul J Lehner 2 collaborations

None None 2 collaborations

Stephanie Reikine 2 collaborations

Stephen H McLaughlin 2 collaborations

Alba Herrero Del Valle 2 collaborations

Rahul Singh 2 collaborations

Anna V Protasio 2 collaborations

Yangci Liu 2 collaborations

Ming-Shih Hwang 1 collaboration

Mathias Pasche 1 collaboration

Leila Mureşan 1 collaboration

Zinan Zhang 1 collaboration

Florian Gothe 1 collaboration

Perrine Pennamen 1 collaboration

John R James 1 collaboration

David McDonald 1 collaboration

Anas M Alazami 1 collaboration

Meghan Acres 1 collaboration

Wolfram Haller 1 collaboration

Claire Bowen 1 collaboration

Rainer Döffinger 1 collaboration

Jan Sinclair 1 collaboration

Shannon Brothers 1 collaboration

Yu Zhang 1 collaboration

Helen F Matthews 1 collaboration

Sophie Naudion 1 collaboration

Fanny Pelluard 1 collaboration

Huda Alajlan 1 collaboration

Yasuhiro Yamazaki 1 collaboration

Luigi D Notarangelo 1 collaboration

James E Thaventhiran 1 collaboration

Karin R Engelhardt 1 collaboration

Hamoud Al-Mousa 1 collaboration

Sophie Hambleton 1 collaboration

Caroline Rooryck 1 collaboration

Michael J Lenardo 1 collaboration

Laura E Farleigh 1 collaboration

Frank Adolf 1 collaboration

Sarah Maslen 1 collaboration

Steven A Kemp 1 collaboration

Dami A Collier 1 collaboration

Rawlings P Datir 1 collaboration

Isabella A T M Ferreira 1 collaboration

Salma Gayed 1 collaboration

Aminu Jahun 1 collaboration

Myra Hosmillo 1 collaboration

Chloe Rees-Spear 1 collaboration

Petra Mlcochova 1 collaboration

Ines Ushiro Lumb 1 collaboration

David J Roberts 1 collaboration

Anita Chandra 1 collaboration

Nigel Temperton 1 collaboration

Katherine Sharrocks 1 collaboration

Elizabeth Blane 1 collaboration

John A G Briggs 1 collaboration

Marit J van Gils 1 collaboration

John R Bradley 1 collaboration

Chris Smith 1 collaboration

Rainer Doffinger 1 collaboration

Lourdes Ceron-Gutierrez 1 collaboration

Gabriela Barcenas-Morales 1 collaboration

David D Pollock 1 collaboration

Richard A Goldstein 1 collaboration

Anna Smielewska 1 collaboration

Jordan P Skittrall 1 collaboration

Theodore Gouliouris 1 collaboration

Ian G Goodfellow 1 collaboration

Effrossyni Gkrania-Klotsas 1 collaboration

Christopher J R Illingworth 1 collaboration

Laura E McCoy 1 collaboration

Ravindra K Gupta 1 collaboration

Zheng-Shan Chong 1 collaboration

Minmin Yu 1 collaboration

M Zaeem Cader 1 collaboration

Rodrigo Pereira de Almeida Rodrigues 1 collaboration

James A West 1 collaboration

Gavin W Sewell 1 collaboration

Muhammad N Md-Ibrahim 1 collaboration

Giuseppe Sirago 1 collaboration

Lukas W Unger 1 collaboration

Ana Belén Iglesias-Romero 1 collaboration

Katharina Ramshorn 1 collaboration

Lea-Maxie Haag 1 collaboration

Svetlana Saveljeva 1 collaboration

Jana-Fabienne Ebel 1 collaboration

Philip Rosenstiel 1 collaboration

Nicole C Kaneider 1 collaboration

James C Lee 1 collaboration

Trevor D Lawley 1 collaboration

Allan Bradley 1 collaboration

Gordon Dougan 1 collaboration

Julian L Griffin 1 collaboration

Arthur Kaser 1 collaboration

Qin Yu 1 collaboration

Marta Seczynska 1 collaboration

Jane Wagstaff 1 collaboration

James C Williamson 1 collaboration

Helen Alemayehu 1 collaboration

Lee J Hopkins 1 collaboration

Alicia C Borgeaud 1 collaboration

Christina Heroven 1 collaboration

Clare E Bryant 1 collaboration

Nikos Nikolopoulos 1 collaboration

Liao Zhang 1 collaboration

Monique Merchant 1 collaboration

Laura Pokorny 1 collaboration

Jemima J Burden 1 collaboration

David Albrecht 1 collaboration

Rebecca Bamford 1 collaboration

Pooja Sridhar 1 collaboration

Timothy J Knowles 1 collaboration

Jason Mercer 1 collaboration

Yuan Wu 1 collaboration

Sai Mong 1 collaboration

Mark T K Cheng 1 collaboration

Brian J Ferguson 1 collaboration

Ninoslav Pandiloski 1 collaboration