M Zaeem Cader

Affiliations

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Publications (25)

Culprit or Bystander: Defective Mitophagy in Alzheimer's Disease.

Frontiers in cell and developmental biology

Avec: Chenglong Xie , Yahyah Aman , Bryan A Adriaanse , M Zameel Cader , Hélène Plun-Favreau , Jian Xiao , Evandro F Fang

Investigation of

Frontiers in molecular neuroscience

Avec: Neven Maksemous , Claire D Blayney , Heidi G Sutherland , Robert A Smith , Rod A Lea , Kim Ngan Tran , Omar Ibrahim , Jeffrey R McArthur , Larisa M Haupt , M Zameel Cader , Rocio K Finol-Urdaneta , David J Adams , Lyn R Griffiths

Lipopolysaccharide distinctively alters human microglia transcriptomes to resemble microglia from Alzheimer's disease mouse models.

Disease models & mechanisms

Avec: Jimena Monzón-Sandoval , Elena Burlacu , Devika Agarwal , Adam E Handel , Liting Wei , John Davis , Sally A Cowley , M Zameel Cader , Caleb Webber

A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases.

Stem cell reports

Avec: Maha Al-Thani , Mary Goodwin-Trotman , Steven Bell , Krushangi Patel , Lauren K Fleming , Catheline Vilain , Marc Abramowicz , Stuart M Allan , Tao Wang , M Zameel Cader , Karen Horsburgh , Tom Van Agtmael , Sanjay Sinha , Hugh S Markus , Alessandra Granata

Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers.

The Journal of biological chemistry

Avec: Heledd H Jarosz-Griffiths , Nicola J Corbett , Helen A Rowland , Kate Fisher , Alys C Jones , Jennifer Baron , Gareth J Howell , Sally A Cowley , Satyan Chintawar , M Zameel Cader , Katherine A B Kellett , Nigel M Hooper

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease.

Nature neuroscience

Avec: Evandro F Fang , Yujun Hou , Konstantinos Palikaras , Bryan A Adriaanse , Jesse S Kerr , Beimeng Yang , Sofie Lautrup , Md Mahdi Hasan-Olive , Domenica Caponio , Xiuli Dan , Paula Rocktäschel , Deborah L Croteau , Mansour Akbari , Nigel H Greig , Tormod Fladby , Hilde Nilsen , M Zameel Cader , Mark P Mattson , Nektarios Tavernarakis , Vilhelm A Bohr

TRESK is a key regulator of nocturnal suprachiasmatic nucleus dynamics and light adaptive responses.

Nature communications

Avec: Tatjana Lalic , Aiste Steponenaite , Liting Wei , Sridhar R Vasudevan , Alistair Mathie , Stuart N Peirson , Gurprit S Lall , M Zameel Cader

The genetics of migraine and the path to precision medicine.

Progress in brain research

Avec: M Zameel Cader

Genome-Wide Association Study Identifies Risk Loci for Cluster Headache.

Annals of neurology

Avec: Emer O'Connor , Carmen Fourier , Caroline Ran , Prasanth Sivakumar , Franziska Liesecke , Laura Southgate , Aster V E Harder , Lisanne S Vijfhuizen , Janice Yip , Nicola Giffin , Nicholas Silver , Fayyaz Ahmed , Isabel C Hostettler , Brendan Davies , M Zameel Cader , Benjamin S Simpson , Roisin Sullivan , Stephanie Efthymiou , Joycee Adebimpe , Olivia Quinn , Ciaran Campbell , Gianpiero L Cavalleri , Michail Vikelis , Tim Kelderman , Koen Paemeleire , Emer Kilbride , Lou Grangeon , Susie Lagrata , Daisuke Danno , Richard Trembath , Nicholas W Wood , Ingrid Kockum , Bendik S Winsvold , Anna Steinberg , Christina Sjöstrand , Elisabet Waldenlind , Jana Vandrovcova , Henry Houlden , Manjit Matharu , Andrea Carmine Belin

High glucose concentrations mask cellular phenotypes in a stem cell model of tuberous sclerosis complex.

Epilepsy & behavior : E&B

Avec: Paula Rocktäschel , Arjune Sen , M Zameel Cader

A causal role for TRESK loss of function in migraine mechanisms.

Brain : a journal of neurology

Avec: Philippa Pettingill , Greg A Weir , Tina Wei , Yukyee Wu , Grace Flower , Tatjana Lalic , Adam Handel , Galbha Duggal , Satyan Chintawar , Jonathan Cheung , Kanisa Arunasalam , Elizabeth Couper , Larisa M Haupt , Lyn R Griffiths , Andrew Bassett , Sally A Cowley , M Zameel Cader

Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism

Avec: Alexandra Pokhilko , Gaia Brezzo , Lahiru Handunnetthi , Raphael Heilig , Rachel Lennon , Colin Smith , Stuart M Allan , Alessandra Granata , Sanjay Sinha , Tao Wang , Hugh S Markus , Alexandra Naba , Roman Fischer , Tom Van Agtmael , Karen Horsburgh , M Zameel Cader

A single nuclear transcriptomic characterisation of mechanisms responsible for impaired angiogenesis and blood-brain barrier function in Alzheimer's disease.

Nature communications

Avec: Stergios Tsartsalis , Hannah Sleven , Nurun Fancy , Frank Wessely , Amy M Smith , Nanet Willumsen , To Ka Dorcas Cheung , Michal J Rokicki , Vicky Chau , Eseoghene Ifie , Combiz Khozoie , Olaf Ansorge , Xin Yang , Marion H Jenkyns , Karen Davey , Aisling McGarry , Robert C J Muirhead , Stephanie Debette , Johanna S Jackson , Axel Montagne , David R Owen , J Scott Miners , Seth Love , Caleb Webber , M Zameel Cader , Paul M Matthews

A disease-associated gene desert directs macrophage inflammation through ETS2.

Nature

Avec: C T Stankey , C Bourges , L M Haag , T Turner-Stokes , A P Piedade , C Palmer-Jones , I Papa , M Silva Dos Santos , Q Zhang , A J Cameron , A Legrini , T Zhang , C S Wood , F N New , L O Randzavola , L Speidel , A C Brown , A Hall , F Saffioti , E C Parkes , W Edwards , H Direskeneli , P C Grayson , L Jiang , P A Merkel , G Saruhan-Direskeneli , A H Sawalha , E Tombetti , A Quaglia , D Thorburn , J C Knight , A P Rochford , C D Murray , P Divakar , M Green , E Nye , J I MacRae , N B Jamieson , P Skoglund , M Z Cader , C Wallace , D C Thomas , J C Lee

Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer's disease.

Stem cell research & therapy

Avec: Despoina Charou , Thanasis Rogdakis , Alessia Latorrata , Maria Valcarcel , Vasileios Papadogiannis , Christina Athanasiou , Alexandros Tsengenes , Maria Anna Papadopoulou , Dimitrios Lypitkas , Matthieu D Lavigne , Theodora Katsila , Rebecca C Wade , M Zameel Cader , Theodora Calogeropoulou , Achille Gravanis , Ioannis Charalampopoulos

From Young to Old: Mimicking Neuronal Aging in Directly Converted Neurons from Young Donors.

Cells

Avec: Nimmy Varghese , Amandine Grimm , M Zameel Cader , Anne Eckert

Patient fibroblast circadian rhythms predict lithium sensitivity in bipolar disorder.

Molecular psychiatry

Avec: Harshmeena R Sanghani , Aarti Jagannath , Thomas Humberstone , Farid Ebrahimjee , Justyn M Thomas , Grant C Churchill , Andrea Cipriani , Mary-Jane Attenburrow , Olga V Perestenko , Sally A Cowley , M Zameel Cader , Stuart N Peirson , Paul J Harrison , Russell G Foster , Guy M Goodwin , Sridhar R Vasudevan

FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.

Cell

Avec: M Zaeem Cader , Rodrigo Pereira de Almeida Rodrigues , James A West , Gavin W Sewell , Muhammad N Md-Ibrahim , Stephanie Reikine , Giuseppe Sirago , Lukas W Unger , Ana Belén Iglesias-Romero , Katharina Ramshorn , Lea-Maxie Haag , Svetlana Saveljeva , Jana-Fabienne Ebel , Philip Rosenstiel , Nicole C Kaneider , James C Lee , Trevor D Lawley , Allan Bradley , Gordon Dougan , Yorgo Modis , Julian L Griffin , Arthur Kaser

Targeted RNA sequencing enhances gene expression profiling of ultra-low input samples.

RNA biology

Avec: Fabiola Curion , Adam E Handel , Moustafa Attar , Giuseppe Gallone , Rory Bowden , M Zameel Cader , Michael B Clark

Common transcriptional signatures of neuropathic pain.

Pain

Avec: Alexandra Pokhilko , Anthony Nash , M Zameel Cader

The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing.

Frontiers in molecular neuroscience

Avec: Greg A Weir , Philippa Pettingill , Yukyee Wu , Galbha Duggal , Andrei-Sorin Ilie , Colin J Akerman , M Zameel Cader

Targeted single-cell RNA sequencing of transcription factors enhances the identification of cell types and trajectories.

Genome research

Avec: Alexandra Pokhilko , Adam E Handel , Fabiola Curion , Viola Volpato , Emma S Whiteley , Sunniva Bøstrand , Sarah E Newey , Colin J Akerman , Caleb Webber , Michael B Clark , Rory Bowden , M Zameel Cader

NOCICEPTRA: Gene and microRNA Signatures and Their Trajectories Characterizing Human iPSC-Derived Nociceptor Maturation.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Avec: Maximilian Zeidler , Kai K Kummer , Clemens L Schöpf , Theodora Kalpachidou , Georg Kern , M Zameel Cader , Michaela Kress

A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.

Cell metabolism

Avec: Svetlana Saveljeva , Gavin W Sewell , Katharina Ramshorn , M Zaeem Cader , James A West , Simon Clare , Lea-Maxie Haag , Rodrigo Pereira de Almeida Rodrigues , Lukas W Unger , Ana Belén Iglesias-Romero , Lorraine M Holland , Christophe Bourges , Muhammad N Md-Ibrahim , James O Jones , Richard S Blumberg , James C Lee , Nicole C Kaneider , Trevor D Lawley , Allan Bradley , Gordon Dougan , Arthur Kaser

Aneuploidy effects on human gene expression across three cell types.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Siyuan Liu , Nirmala Akula , Paul K Reardon , Jill Russ , Erin Torres , Liv S Clasen , Jonathan Blumenthal , Francois Lalonde , Francis J McMahon , Francis Szele , Christine M Disteche , M Zameel Cader , Armin Raznahan

Réseau de co-auteurs

M Zameel Cader 22 collaborations

Sally A Cowley 4 collaborations

Adam E Handel 3 collaborations

Caleb Webber 3 collaborations

Alexandra Pokhilko 3 collaborations

Bryan A Adriaanse 2 collaborations

Evandro F Fang 2 collaborations

Larisa M Haupt 2 collaborations

Lyn R Griffiths 2 collaborations

Liting Wei 2 collaborations

Stuart M Allan 2 collaborations

Tao Wang 2 collaborations

Karen Horsburgh 2 collaborations

Tom Van Agtmael 2 collaborations

Sanjay Sinha 2 collaborations

Hugh S Markus 2 collaborations

Alessandra Granata 2 collaborations

Satyan Chintawar 2 collaborations

Paula Rocktäschel 2 collaborations

Tatjana Lalic 2 collaborations

Sridhar R Vasudevan 2 collaborations

Stuart N Peirson 2 collaborations

Philippa Pettingill 2 collaborations

Greg A Weir 2 collaborations

Yukyee Wu 2 collaborations

Galbha Duggal 2 collaborations

Rodrigo Pereira de Almeida Rodrigues 2 collaborations

James A West 2 collaborations

Gavin W Sewell 2 collaborations

Muhammad N Md-Ibrahim 2 collaborations

Lukas W Unger 2 collaborations

Ana Belén Iglesias-Romero 2 collaborations

Katharina Ramshorn 2 collaborations

Lea-Maxie Haag 2 collaborations

Svetlana Saveljeva 2 collaborations

Nicole C Kaneider 2 collaborations

James C Lee 2 collaborations

Trevor D Lawley 2 collaborations

Allan Bradley 2 collaborations

Gordon Dougan 2 collaborations

Arthur Kaser 2 collaborations

Fabiola Curion 2 collaborations

Rory Bowden 2 collaborations

Michael B Clark 2 collaborations

Colin J Akerman 2 collaborations

Chenglong Xie 1 collaboration

Yahyah Aman 1 collaboration

Hélène Plun-Favreau 1 collaboration

Jian Xiao 1 collaboration

Neven Maksemous 1 collaboration

Claire D Blayney 1 collaboration

Heidi G Sutherland 1 collaboration

Robert A Smith 1 collaboration

Rod A Lea 1 collaboration

Kim Ngan Tran 1 collaboration

Omar Ibrahim 1 collaboration

Jeffrey R McArthur 1 collaboration

Rocio K Finol-Urdaneta 1 collaboration

David J Adams 1 collaboration

Jimena Monzón-Sandoval 1 collaboration

Elena Burlacu 1 collaboration

Devika Agarwal 1 collaboration

John Davis 1 collaboration

Maha Al-Thani 1 collaboration

Mary Goodwin-Trotman 1 collaboration

Steven Bell 1 collaboration

Krushangi Patel 1 collaboration

Lauren K Fleming 1 collaboration

Catheline Vilain 1 collaboration

Marc Abramowicz 1 collaboration

Heledd H Jarosz-Griffiths 1 collaboration

Nicola J Corbett 1 collaboration

Helen A Rowland 1 collaboration

Kate Fisher 1 collaboration

Alys C Jones 1 collaboration

Jennifer Baron 1 collaboration

Gareth J Howell 1 collaboration

Katherine A B Kellett 1 collaboration

Nigel M Hooper 1 collaboration

Yujun Hou 1 collaboration

Konstantinos Palikaras 1 collaboration

Jesse S Kerr 1 collaboration

Beimeng Yang 1 collaboration

Sofie Lautrup 1 collaboration

Md Mahdi Hasan-Olive 1 collaboration

Domenica Caponio 1 collaboration

Xiuli Dan 1 collaboration

Deborah L Croteau 1 collaboration

Mansour Akbari 1 collaboration

Nigel H Greig 1 collaboration

Tormod Fladby 1 collaboration

Hilde Nilsen 1 collaboration

Mark P Mattson 1 collaboration

Nektarios Tavernarakis 1 collaboration

Vilhelm A Bohr 1 collaboration

Aiste Steponenaite 1 collaboration

Alistair Mathie 1 collaboration

Gurprit S Lall 1 collaboration

Emer O'Connor 1 collaboration

Carmen Fourier 1 collaboration

Caroline Ran 1 collaboration

Prasanth Sivakumar 1 collaboration

Franziska Liesecke 1 collaboration

Laura Southgate 1 collaboration

Aster V E Harder 1 collaboration

Lisanne S Vijfhuizen 1 collaboration

Janice Yip 1 collaboration

Nicola Giffin 1 collaboration

Nicholas Silver 1 collaboration

Fayyaz Ahmed 1 collaboration

Isabel C Hostettler 1 collaboration

Brendan Davies 1 collaboration

Benjamin S Simpson 1 collaboration

Roisin Sullivan 1 collaboration

Stephanie Efthymiou 1 collaboration

Joycee Adebimpe 1 collaboration

Olivia Quinn 1 collaboration

Ciaran Campbell 1 collaboration

Gianpiero L Cavalleri 1 collaboration

Michail Vikelis 1 collaboration

Tim Kelderman 1 collaboration

Koen Paemeleire 1 collaboration

Emer Kilbride 1 collaboration

Lou Grangeon 1 collaboration

Susie Lagrata 1 collaboration

Daisuke Danno 1 collaboration

Richard Trembath 1 collaboration

Nicholas W Wood 1 collaboration

Ingrid Kockum 1 collaboration

Bendik S Winsvold 1 collaboration

Anna Steinberg 1 collaboration

Christina Sjöstrand 1 collaboration

Elisabet Waldenlind 1 collaboration

Jana Vandrovcova 1 collaboration

Henry Houlden 1 collaboration

Manjit Matharu 1 collaboration

Andrea Carmine Belin 1 collaboration

Arjune Sen 1 collaboration

Tina Wei 1 collaboration

Grace Flower 1 collaboration

Adam Handel 1 collaboration

Jonathan Cheung 1 collaboration

Kanisa Arunasalam 1 collaboration

Elizabeth Couper 1 collaboration

Andrew Bassett 1 collaboration

Gaia Brezzo 1 collaboration

Lahiru Handunnetthi 1 collaboration

Raphael Heilig 1 collaboration

Rachel Lennon 1 collaboration

Colin Smith 1 collaboration

Alexandra Naba 1 collaboration

Roman Fischer 1 collaboration

Stergios Tsartsalis 1 collaboration

Hannah Sleven 1 collaboration

Nurun Fancy 1 collaboration

Frank Wessely 1 collaboration

Amy M Smith 1 collaboration

Nanet Willumsen 1 collaboration

To Ka Dorcas Cheung 1 collaboration

Michal J Rokicki 1 collaboration

Vicky Chau 1 collaboration

Eseoghene Ifie 1 collaboration

Combiz Khozoie 1 collaboration

Olaf Ansorge 1 collaboration

Xin Yang 1 collaboration

Marion H Jenkyns 1 collaboration

Karen Davey 1 collaboration

Aisling McGarry 1 collaboration

Robert C J Muirhead 1 collaboration

Stephanie Debette 1 collaboration

Johanna S Jackson 1 collaboration

Axel Montagne 1 collaboration

David R Owen 1 collaboration

J Scott Miners 1 collaboration

Seth Love 1 collaboration

Paul M Matthews 1 collaboration

C T Stankey 1 collaboration

C Bourges 1 collaboration

L M Haag 1 collaboration

T Turner-Stokes 1 collaboration

A P Piedade 1 collaboration

C Palmer-Jones 1 collaboration

I Papa 1 collaboration

M Silva Dos Santos 1 collaboration

Q Zhang 1 collaboration

A J Cameron 1 collaboration

A Legrini 1 collaboration

T Zhang 1 collaboration

C S Wood 1 collaboration

F N New 1 collaboration

L O Randzavola 1 collaboration

L Speidel 1 collaboration

A C Brown 1 collaboration

A Hall 1 collaboration

F Saffioti 1 collaboration

E C Parkes 1 collaboration

W Edwards 1 collaboration

H Direskeneli 1 collaboration

P C Grayson 1 collaboration

L Jiang 1 collaboration

P A Merkel 1 collaboration

G Saruhan-Direskeneli 1 collaboration

A H Sawalha 1 collaboration

E Tombetti 1 collaboration

A Quaglia 1 collaboration

D Thorburn 1 collaboration

J C Knight 1 collaboration

A P Rochford 1 collaboration

C D Murray 1 collaboration

P Divakar 1 collaboration

M Green 1 collaboration

E Nye 1 collaboration

J I MacRae 1 collaboration

N B Jamieson 1 collaboration

P Skoglund 1 collaboration

M Z Cader 1 collaboration

C Wallace 1 collaboration

D C Thomas 1 collaboration

J C Lee 1 collaboration

Despoina Charou 1 collaboration

Thanasis Rogdakis 1 collaboration

Alessia Latorrata 1 collaboration

Maria Valcarcel 1 collaboration

Vasileios Papadogiannis 1 collaboration

Christina Athanasiou 1 collaboration

Alexandros Tsengenes 1 collaboration

Maria Anna Papadopoulou 1 collaboration

Dimitrios Lypitkas 1 collaboration

Matthieu D Lavigne 1 collaboration

Theodora Katsila 1 collaboration

Rebecca C Wade 1 collaboration

Theodora Calogeropoulou 1 collaboration

Achille Gravanis 1 collaboration

Ioannis Charalampopoulos 1 collaboration

Nimmy Varghese 1 collaboration

Amandine Grimm 1 collaboration

Anne Eckert 1 collaboration

Harshmeena R Sanghani 1 collaboration

Aarti Jagannath 1 collaboration

Thomas Humberstone 1 collaboration

Farid Ebrahimjee 1 collaboration

Justyn M Thomas 1 collaboration

Grant C Churchill 1 collaboration

Andrea Cipriani 1 collaboration

Mary-Jane Attenburrow 1 collaboration

Olga V Perestenko 1 collaboration

Paul J Harrison 1 collaboration

Russell G Foster 1 collaboration

Guy M Goodwin 1 collaboration

Stephanie Reikine 1 collaboration

Giuseppe Sirago 1 collaboration

Jana-Fabienne Ebel 1 collaboration

Philip Rosenstiel 1 collaboration

Yorgo Modis 1 collaboration

Julian L Griffin 1 collaboration

Moustafa Attar 1 collaboration

Giuseppe Gallone 1 collaboration

Anthony Nash 1 collaboration

Andrei-Sorin Ilie 1 collaboration

Viola Volpato 1 collaboration

Emma S Whiteley 1 collaboration

Sunniva Bøstrand 1 collaboration

Sarah E Newey 1 collaboration

Maximilian Zeidler 1 collaboration

Kai K Kummer 1 collaboration

Clemens L Schöpf 1 collaboration

Theodora Kalpachidou 1 collaboration

Georg Kern 1 collaboration

Michaela Kress 1 collaboration

Simon Clare 1 collaboration

Lorraine M Holland 1 collaboration

Christophe Bourges 1 collaboration

James O Jones 1 collaboration

Richard S Blumberg 1 collaboration

Siyuan Liu 1 collaboration

Nirmala Akula 1 collaboration

Paul K Reardon 1 collaboration

Jill Russ 1 collaboration

Erin Torres 1 collaboration

Liv S Clasen 1 collaboration

Jonathan Blumenthal 1 collaboration

Francois Lalonde 1 collaboration

Francis J McMahon 1 collaboration

Francis Szele 1 collaboration

Christine M Disteche 1 collaboration

Armin Raznahan 1 collaboration