A purine metabolic checkpoint that prevents autoimmunity and autoinflammation.

Autoimmunity CD8-Positive T-Lymphocytes Dendritic Cells Lymphocyte Activation Purines / metabolism
NADH/NAD(+) reductive stress T cell priming autoimmunity dendritic cells membrane trafficking purine nucleotide cycle

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
04 01 2022
Historique:
received: 18 06 2021
revised: 28 09 2021
accepted: 08 12 2021
entrez: 5 1 2022
pubmed: 6 1 2022
medline: 8 4 2022
Statut: ppublish

Résumé

Still's disease, the paradigm of autoinflammation-cum-autoimmunity, predisposes for a cytokine storm with excessive T lymphocyte activation upon viral infection. Loss of function of the purine nucleoside enzyme FAMIN is the sole known cause for monogenic Still's disease. Here we discovered that a FAMIN-enabled purine metabolon in dendritic cells (DCs) restrains CD4

Identifiants

DOI: 10.1016/j.cmet.2021.12.009 PMID: 34986329 PMC: PMC8730334
pubmed: 34986329
pii: S1550-4131(21)00628-8
doi: 10.1016/j.cmet.2021.12.009
pmc: PMC8730334
pii:
doi:

Substances chimiques

Purines 0
purine W60KTZ3IZY

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

106-124.e10

Subventions

Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Austrian Science Fund FWF
ID : J 4396
Pays : Austria
Organisme : NIDDK NIH HHS
ID : R01 DK051362
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK088199
Pays : United States
Organisme : Wellcome Trust
ID : 106260/Z/14/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 222497/Z/21/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 105920/Z/14/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 216630/Z/19/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103077/Z/13/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 222056/Z/20/Z
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 102163/B/13/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00014/5
Pays : United Kingdom

Informations de copyright

Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The University of Cambridge has filed patent applications relating to this work. The authors declare no other competing financial interests.

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Auteurs

Svetlana Saveljeva (S)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Gavin W Sewell (GW)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Katharina Ramshorn (K)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

M Zaeem Cader (MZ)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

James A West (JA)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Simon Clare (S)

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

Lea-Maxie Haag (LM)

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Rodrigo Pereira de Almeida Rodrigues (RP)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Lukas W Unger (LW)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Ana Belén Iglesias-Romero (AB)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Lorraine M Holland (LM)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Christophe Bourges (C)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Muhammad N Md-Ibrahim (MN)

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

James O Jones (JO)

Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Richard S Blumberg (RS)

Division of Gastroenterology, Hepatology and Endoscopy, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.

James C Lee (JC)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Nicole C Kaneider (NC)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Trevor D Lawley (TD)

Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK.

Allan Bradley (A)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK.

Gordon Dougan (G)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Infectious Diseases, Department of Medicine, University of Cambridge, Cambridge CB2 0QQ, UK.

Arthur Kaser (A)

Cambridge Institute of Therapeutic Immunology and Infectious Disease, Jeffrey Cheah Biomedical Centre, University of Cambridge, Cambridge CB2 0AW, UK; Division of Gastroenterology and Hepatology, Department of Medicine, University of Cambridge, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK. Electronic address: ak729@cam.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Auto-immunité › A purine metabolic checkpoint that prevents...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › A purine metabolic checkpoint that prevents...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système phagocytaire mononucléé › Cellules dendritiques › A purine metabolic checkpoint that prevents...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › A purine metabolic checkpoint that prevents...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › A purine metabolic checkpoint that prevents...