Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
Animals
Cerebellar Neoplasms
/ classification
Cerebellum
/ cytology
Child
Evolution, Molecular
Female
Fetus
/ cytology
Gene Expression Regulation, Developmental
Gene Expression Regulation, Neoplastic
Glioma
/ classification
Humans
Medulloblastoma
/ classification
Mice
Sequence Analysis, RNA
Single-Cell Analysis
Time Factors
Transcription, Genetic
Transcriptome
/ genetics
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
20
06
2018
accepted:
22
03
2019
pubmed:
3
5
2019
medline:
20
11
2019
entrez:
3
5
2019
Statut:
ppublish
Résumé
Study of the origin and development of cerebellar tumours has been hampered by the complexity and heterogeneity of cerebellar cells that change over the course of development. Here we use single-cell transcriptomics to study more than 60,000 cells from the developing mouse cerebellum and show that different molecular subgroups of childhood cerebellar tumours mirror the transcription of cells from distinct, temporally restricted cerebellar lineages. The Sonic Hedgehog medulloblastoma subgroup transcriptionally mirrors the granule cell hierarchy as expected, while group 3 medulloblastoma resembles Nestin
Identifiants
pubmed: 31043743
doi: 10.1038/s41586-019-1158-7
pii: 10.1038/s41586-019-1158-7
pmc: PMC6675628
mid: NIHMS1525286
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
67-73Subventions
Organisme : NIMH NIH HHS
ID : R37 MH085726
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH085726
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS092096
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA148699
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS106155
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA159859
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA192176
Pays : United States
Commentaires et corrections
Type : CommentIn
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