Antitrypanosomal Activity of Acetogenins Isolated from the Seeds of Porcelia macrocarpa Is Associated with Alterations in Both Plasma Membrane Electric Potential and Mitochondrial Membrane Potential.

Acetogenins / chemistry Annonaceae / chemistry Cell Membrane / drug effects Cell Membrane Permeability / drug effects Magnetic Resonance Spectroscopy Membrane Potential, Mitochondrial / drug effects Seeds / chemistry Trypanocidal Agents / pharmacology Trypanosoma cruzi / drug effects

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
24 05 2019
Historique:
pubmed: 3 5 2019
medline: 29 8 2020
entrez: 4 5 2019
Statut: ppublish

Résumé

As part of a drug discovery program aimed at the identification of anti- Trypanosoma cruzi metabolites from Brazilian flora, four acetogenins (1-4) were isolated from the seeds of Porcelia macrocarpa and were identified by NMR spectroscopy and HRESIMS. The new compounds 1 and 2 displayed activity against the trypomastigote (IC

Identifiants

DOI: 10.1021/acs.jnatprod.8b00890 PMID: 31046273
pubmed: 31046273
doi: 10.1021/acs.jnatprod.8b00890
doi:

Substances chimiques

Acetogenins 0
Trypanocidal Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1177-1182

Auteurs

Emerson A Oliveira (EA)

Institute of Environmental, Chemical and Pharmaceutical Sciences , Federal University of São Paulo , São Paulo 09972-270 , Brazil.

Ivanildo A Brito (IA)

Center for Natural and Human Sciences , Federal University of ABC , São Paulo 09606-045 , Brazil.

Marta L Lima (ML)

Centre for Parasitology and Mycology , Instituto Adolfo Lutz , São Paulo 01246-000 , Brazil.

Maiara Romanelli (M)

Centre for Parasitology and Mycology , Instituto Adolfo Lutz , São Paulo 01246-000 , Brazil.

José T Moreira-Filho (JT)

Faculty of Pharmacy , Federal University of Goias , Goias 74605-170 , Brazil.

Bruno J Neves (BJ)

Faculty of Pharmacy , Federal University of Goias , Goias 74605-170 , Brazil.
Laboratory of Cheminformatics , University Center of Anápolis , Goias 75083-515 , Brazil.

Carolina H Andrade (CH)

Faculty of Pharmacy , Federal University of Goias , Goias 74605-170 , Brazil.
ORCID: 0000-0003-0101-1492

Patricia Sartorelli (P)

Institute of Environmental, Chemical and Pharmaceutical Sciences , Federal University of São Paulo , São Paulo 09972-270 , Brazil.

Andre G Tempone (AG)

Centre for Parasitology and Mycology , Instituto Adolfo Lutz , São Paulo 01246-000 , Brazil.

Thais A Costa-Silva (TA)

Center for Natural and Human Sciences , Federal University of ABC , São Paulo 09606-045 , Brazil.

João Henrique G Lago (JHG)

Center for Natural and Human Sciences , Federal University of ABC , São Paulo 09606-045 , Brazil.
ORCID: 0000-0002-1193-8374

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Classifications MeSH

questionsmedicales.fr › Lipides › Alcools gras › Acétogénines › Antitrypanosomal Activity of Acetogenins...
questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Annonaceae › Antitrypanosomal Activity of Acetogenins...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Antitrypanosomal Activity of Acetogenins...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Perméabilité des membranes cellulaires › Antitrypanosomal Activity of Acetogenins...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Analyse spectrale › Spectroscopie par résonance magnétique › Antitrypanosomal Activity of Acetogenins...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes électrophysiologiques › Potentiel de membrane mitochondriale › Antitrypanosomal Activity of Acetogenins...
questionsmedicales.fr › Aliments et boissons › Aliments › Graines › Antitrypanosomal Activity of Acetogenins...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antiparasitaires › Antiprotozoaires › Trypanocides › Antitrypanosomal Activity of Acetogenins...
questionsmedicales.fr › Eucaryotes › Euglénozoaires › Kinetoplastida › Trypanosomatina › Trypanosoma › Trypanosoma cruzi › Antitrypanosomal Activity of Acetogenins...