Periostin, type 2 biomarker, is not associated with asthma control grade in asthmatic allergic children.
Asthma
/ blood
Biomarkers
/ blood
Cell Adhesion Molecules
/ blood
Child
Cross-Sectional Studies
Eosinophils
/ metabolism
Exhalation
Female
Glucocorticoids
/ therapeutic use
Humans
Immunoglobulin E
/ blood
Male
Nitric Oxide
/ metabolism
Respiratory Function Tests
Severity of Illness Index
Sex Factors
Asthma
Asthma control
Children
Eosinophils
Inflammation
Periostin
Journal
Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
18
11
2018
revised:
07
04
2019
accepted:
09
04
2019
entrez:
4
5
2019
pubmed:
3
5
2019
medline:
7
5
2020
Statut:
ppublish
Résumé
Allergic asthma is characterized by type 2 inflammation. Periostin has been proposed as type 2 biomarker. To test the hypothesis that serum periostin could be associated with the asthma control grade in a group of children with allergic asthma and recruited in clinical practice. 121 consecutive children (71 males, 50 females, mean age 11.6 ± 3.2 years) with allergic asthma were visited for the first time at a third-level paediatric clinic. Serum periostin was evaluated with gender, BMI and z score BMI, lung function, FeNO, ACT questionnaire, VAS of breathing perception, peripheral eosinophils, total serum IgE, oral corticosteroid (CS) use in the past year, control asthma grade and asthma severity (according to GINA document). Serum periostin was not associated with the asthma control grade and did not correlate with blood eosinophils and FeNO. In addition, peripheral eosinophils, serum IgE, and FeNO were not associated with the asthma control grade. On the contrary, gender, FEV Serum periostin seems to be scarcely useful to assess the asthma control in children with allergic asthma in clinical practice. There is the need to identify reliable inflammation biomarkers able to correlate with the asthma control grade.
Sections du résumé
BACKGROUND
Allergic asthma is characterized by type 2 inflammation. Periostin has been proposed as type 2 biomarker.
OBJECTIVE
To test the hypothesis that serum periostin could be associated with the asthma control grade in a group of children with allergic asthma and recruited in clinical practice.
PATIENTS AND METHODS
121 consecutive children (71 males, 50 females, mean age 11.6 ± 3.2 years) with allergic asthma were visited for the first time at a third-level paediatric clinic. Serum periostin was evaluated with gender, BMI and z score BMI, lung function, FeNO, ACT questionnaire, VAS of breathing perception, peripheral eosinophils, total serum IgE, oral corticosteroid (CS) use in the past year, control asthma grade and asthma severity (according to GINA document).
RESULTS
Serum periostin was not associated with the asthma control grade and did not correlate with blood eosinophils and FeNO. In addition, peripheral eosinophils, serum IgE, and FeNO were not associated with the asthma control grade. On the contrary, gender, FEV
CONCLUSIONS
Serum periostin seems to be scarcely useful to assess the asthma control in children with allergic asthma in clinical practice. There is the need to identify reliable inflammation biomarkers able to correlate with the asthma control grade.
Identifiants
pubmed: 31047107
pii: S0954-6111(19)30131-3
doi: 10.1016/j.rmed.2019.04.010
pii:
doi:
Substances chimiques
Biomarkers
0
Cell Adhesion Molecules
0
Glucocorticoids
0
POSTN protein, human
0
Nitric Oxide
31C4KY9ESH
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
118-120Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.