Extensive global movement of multidrug-resistant
clinical epidemiology
tuberculosis
Journal
Thorax
ISSN: 1468-3296
Titre abrégé: Thorax
Pays: England
ID NLM: 0417353
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
12
02
2018
revised:
28
01
2019
accepted:
25
02
2019
pubmed:
3
5
2019
medline:
19
5
2020
entrez:
4
5
2019
Statut:
ppublish
Résumé
While the international spread of multidrug-resistant (MDR) In a global dataset of 5310 Extensive international dissemination of MDR-TB was observed, with identification of 32 migrant MDR-TB clades with descendants isolated in 17 unique countries. Relatively recent movement of strains from both Beijing and non-Beijing lineages indicated successful global spread of varied genetic backgrounds. Migrant MDR-TB clade members shared relatively recent common ancestry, with a median estimate of divergence of 13-27 years. Migrant extensively drug-resistant (XDR)-TB clades were not observed, although development of XDR-TB within migratory MDR-TB clades was common. Application of genomic techniques to investigate global MDR migration patterns revealed extensive global spread of MDR clades between countries of varying TB burden. Further expansion of genomic studies to incorporate isolates from diverse global settings into a single analysis, as well as data sharing platforms that facilitate genomic data sharing across country lines, may allow for future epidemiological analyses to monitor for international transmission of MDR-TB. In addition, efforts to perform routine whole-genome sequencing on all newly identified
Sections du résumé
BACKGROUND
While the international spread of multidrug-resistant (MDR)
METHODS
In a global dataset of 5310
RESULTS
Extensive international dissemination of MDR-TB was observed, with identification of 32 migrant MDR-TB clades with descendants isolated in 17 unique countries. Relatively recent movement of strains from both Beijing and non-Beijing lineages indicated successful global spread of varied genetic backgrounds. Migrant MDR-TB clade members shared relatively recent common ancestry, with a median estimate of divergence of 13-27 years. Migrant extensively drug-resistant (XDR)-TB clades were not observed, although development of XDR-TB within migratory MDR-TB clades was common.
CONCLUSIONS
Application of genomic techniques to investigate global MDR migration patterns revealed extensive global spread of MDR clades between countries of varying TB burden. Further expansion of genomic studies to incorporate isolates from diverse global settings into a single analysis, as well as data sharing platforms that facilitate genomic data sharing across country lines, may allow for future epidemiological analyses to monitor for international transmission of MDR-TB. In addition, efforts to perform routine whole-genome sequencing on all newly identified
Identifiants
pubmed: 31048508
pii: thoraxjnl-2018-211616
doi: 10.1136/thoraxjnl-2018-211616
pmc: PMC6788793
mid: NIHMS1053865
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
882-889Subventions
Organisme : NIAID NIH HHS
ID : HHSN272200900018C
Pays : United States
Organisme : NHLBI NIH HHS
ID : K08 HL139994
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007633
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI110818
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
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