Stage-specific requirement for Mettl3-dependent m

Adenosine / analogs & derivatives Animals Bone Marrow Cells / cytology Cell Differentiation / genetics Gene Expression Regulation, Developmental / genetics Hematopoietic Stem Cells / cytology Methylation Methyltransferases / genetics Mice Proto-Oncogene Proteins c-myc / genetics RNA, Messenger / genetics Sequence Analysis, RNA

Journal

Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575

Informations de publication

Date de publication:
06 2019
Historique:
received: 03 07 2018
accepted: 25 03 2019
pubmed: 8 5 2019
medline: 10 7 2019
entrez: 8 5 2019
Statut: ppublish

Résumé

Haematopoietic stem cells (HSCs) maintain balanced self-renewal and differentiation, but how these functions are precisely regulated is not fully understood. N

Identifiants

DOI: 10.1038/s41556-019-0318-1 PMID: 31061465 PMC: PMC6556891
pubmed: 31061465
doi: 10.1038/s41556-019-0318-1
pii: 10.1038/s41556-019-0318-1
pmc: PMC6556891
mid: NIHMS1525419
doi:

Substances chimiques

Myc protein, mouse 0
Proto-Oncogene Proteins c-myc 0
RNA, Messenger 0
N-methyladenosine CLE6G00625
Methyltransferases EC 2.1.1.-
Mettl3 protein, mouse EC 2.1.1.-
Adenosine K72T3FS567

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

700-709

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS089676
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132074
Pays : United States
Organisme : NHGRI NIH HHS
ID : R03 HG009528
Pays : United States
Organisme : NHLBI NIH HHS
ID : F30 HL142196
Pays : United States
Organisme : NIGMS NIH HHS
ID : T32 GM007367
Pays : United States
Organisme : European Research Council
ID : 726497
Pays : International
Organisme : NIGMS NIH HHS
ID : R01 GM124486
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA013696
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL153487
Pays : United States

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Auteurs

Heather Lee (H)

Columbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine and Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA.

Suying Bao (S)

Department of Systems Biology and Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY, USA.

Yingzhi Qian (Y)

Department of Systems Biology and Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY, USA.

Shay Geula (S)

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel.

Juliana Leslie (J)

Columbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine and Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA.

Chaolin Zhang (C)

Department of Systems Biology and Department of Biochemistry and Molecular Biophysics, Center for Motor Neuron Biology and Disease, Columbia University Medical Center, New York, NY, USA.

Jacob H Hanna (JH)

Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, Israel. Jacob.hanna@weizmann.ac.il.
ORCID: 0000-0003-2042-9974

Lei Ding (L)

Columbia Stem Cell Initiative, Department of Rehabilitation and Regenerative Medicine and Department of Microbiology and Immunology, Columbia University Medical Center, New York, NY, USA. ld2567@cumc.columbia.edu.
ORCID: 0000-0003-4869-8877

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Classifications MeSH

questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléosides › Ribonucléosides › Adénosine › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Eucaryotes › Animaux › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système hématopoïétique › Cellules de la moelle osseuse › Cellules souches hématopoïétiques › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Métabolisme › Alkylation › Méthylation › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › One-carbon group transferases › Methyltransferases › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Protéines proto-oncogènes c-myc › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ARN › ARN messager › Stage-specific requirement for Mettl3-dependent m
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › Stage-specific requirement for Mettl3-dependent m