Ring opening of epoxides with [
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
30 May 2019
30 May 2019
Historique:
pubmed:
8
5
2019
medline:
14
6
2019
entrez:
8
5
2019
Statut:
ppublish
Résumé
A simple technique for the preparation of [18F]HF has been developed and applied to the generation of an [18F]FeF species for opening sterically hindered epoxides. This method has been successfully employed to prepare four drug-like molecules, including 5-[18F]fluoro-6-hydroxy-cholesterol, a potential adrenal/endocrine PET imaging agent. This easily automated one-pot procedure produces sterically hindered fluorohydrin PET imaging agents in good yields and high molar activities.
Identifiants
pubmed: 31062010
doi: 10.1039/c9cc02779c
pmc: PMC6542722
mid: NIHMS1026657
doi:
Substances chimiques
Epoxy Compounds
0
Fluorine Radioisotopes
0
Hydrocarbons, Fluorinated
0
Radiopharmaceuticals
0
Iron
E1UOL152H7
Fluorides
Q80VPU408O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
6361-6364Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB021155
Pays : United States
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