Gene expression and DNA methylation as mechanisms of disturbed metabolism in offspring after exposure to a prenatal HF diet.
Animals
Cell Proliferation
/ drug effects
DNA
/ metabolism
DNA Methylation
/ drug effects
Diet, High-Fat
/ adverse effects
High-Throughput Nucleotide Sequencing
Lipid Metabolism
/ drug effects
Liver
/ drug effects
Male
Mice, Inbred C57BL
Oxidation-Reduction
/ drug effects
Oxidative Stress
/ drug effects
Phosphatidate Phosphatase
/ genetics
Real-Time Polymerase Chain Reaction
deoxyribonucleic acid
development
diet and dietary lipids
epigenetics
high-fat diet
in utero
lipid metabolism
liver
microarrays
obesity
oxidative stress
pregnancy
Journal
Journal of lipid research
ISSN: 1539-7262
Titre abrégé: J Lipid Res
Pays: United States
ID NLM: 0376606
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
21
01
2019
revised:
03
05
2019
pubmed:
9
5
2019
medline:
14
7
2020
entrez:
9
5
2019
Statut:
ppublish
Résumé
Exposure to a prenatal high-fat (HF) diet leads to an impaired metabolic phenotype in mouse offspring. The underlying mechanisms, however, are not yet fully understood. Therefore, this study investigated whether the impaired metabolic phenotype may be mediated through altered hepatic DNA methylation and gene expression. We showed that exposure to a prenatal HF diet altered the offspring's hepatic gene expression of pathways involved in lipid synthesis and uptake (SREBP), oxidative stress response [nuclear factor (erythroid-derived 2)-like 2 (Nrf2)], and cell proliferation. The downregulation of the SREBP pathway related to previously reported decreased hepatic lipid uptake and postprandial hypertriglyceridemia in the offspring exposed to the prenatal HF diet. The upregulation of the Nrf2 pathway was associated with increased oxidative stress levels in offspring livers. The prenatal HF diet also induced hypermethylation of transcription factor (TF) binding sites upstream of lipin 1 (
Identifiants
pubmed: 31064776
pii: S0022-2275(20)31057-9
doi: 10.1194/jlr.M092593
pmc: PMC6602131
doi:
Substances chimiques
DNA
9007-49-2
Lpin1 protein, mouse
EC 3.1.3.4
Phosphatidate Phosphatase
EC 3.1.3.4
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1250-1259Informations de copyright
Copyright © 2019 Rouschop et al. Published by The American Society for Biochemistry and Molecular Biology, Inc.
Références
Am J Clin Nutr. 1999 Nov;70(5):811-6
pubmed: 10539740
Nucleic Acids Res. 2000 Jan 1;28(1):27-30
pubmed: 10592173
Heart. 2000 Dec;84(6):595-8
pubmed: 11083734
Biochem Biophys Res Commun. 2001 Aug 10;286(1):176-83
pubmed: 11485325
Hepatology. 2001 Oct;34(4 Pt 1):694-706
pubmed: 11584365
Methods. 2001 Dec;25(4):402-8
pubmed: 11846609
J Clin Invest. 2002 May;109(9):1125-31
pubmed: 11994399
Bioinformatics. 2003 Jan 22;19(2):185-93
pubmed: 12538238
Nucleic Acids Res. 2003 Dec 15;31(24):e154
pubmed: 14654707
Circulation. 2004 Aug 31;110(9):1097-102
pubmed: 15326063
Nat Rev Mol Cell Biol. 2004 Oct;5(10):836-47
pubmed: 15459664
Proc Natl Acad Sci U S A. 2005 Oct 25;102(43):15545-50
pubmed: 16199517
Hepatology. 2005 Nov;42(5):1148-57
pubmed: 16231352
Hepatology. 2006 Feb;43(2 Suppl 1):S45-53
pubmed: 16447274
Diabetologia. 2006 Apr;49(4):637-43
pubmed: 16470406
Cell Metab. 2006 Sep;4(3):199-210
pubmed: 16950137
Nucleic Acids Res. 2007 Jan;35(Database issue):D805-9
pubmed: 17068075
BMC Bioinformatics. 2006 Dec 19;7:538
pubmed: 17177995
Nat Protoc. 2006;1(6):3159-65
pubmed: 17406579
J Cell Physiol. 2007 Nov;213(2):286-300
pubmed: 17559071
J Lipid Res. 2008 Dec;49(12):2493-503
pubmed: 18791037
Am J Clin Nutr. 2009 Feb;89(2):551-7
pubmed: 19106237
Eur J Pharmacol. 2009 Oct 12;620(1-3):138-44
pubmed: 19698707
Am J Clin Nutr. 2010 Oct;92(4):946-53
pubmed: 20702606
J Integr Bioinform. 2011 Jul 21;8(2):160
pubmed: 21778530
PLoS One. 2011;6(7):e21662
pubmed: 21779332
Circulation. 2012 Mar 20;125(11):1381-9
pubmed: 22344037
Endocr Rev. 2013 Jun;34(3):309-38
pubmed: 23460719
PLoS One. 2013 Apr 16;8(4):e61627
pubmed: 23613888
J Lipid Res. 2013 Dec;54(12):3269-80
pubmed: 23981283
Int J Obes (Lond). 2015 Apr;39(4):650-7
pubmed: 24158121
PLoS One. 2013 Nov 05;8(11):e78623
pubmed: 24223833
Acta Physiol (Oxf). 2014 Jan;210(1):215-27
pubmed: 24224789
Health Place. 2014 Mar;26:69-77
pubmed: 24378461
Hypertension. 2014 Apr;63(4):683-91
pubmed: 24379180
PLoS One. 2014 Mar 03;9(3):e90335
pubmed: 24594983
Ann Med. 2014 Sep;46(6):434-8
pubmed: 24910160
Front Behav Neurosci. 2014 Aug 22;8:285
pubmed: 25202246
Ann Nutr Metab. 2015;66(1):10-8
pubmed: 25678092
Obesity (Silver Spring). 2015 Apr;23(4):713-9
pubmed: 25755205
Physiol Rep. 2015 Mar;3(3):null
pubmed: 25804263
PLoS One. 2015 Apr 16;10(4):e0124737
pubmed: 25880318
Epigenetics. 2015;10(9):861-71
pubmed: 26252449
Obesity (Silver Spring). 2015 Nov;23(11):2242-50
pubmed: 26530934
Nucleic Acids Res. 2016 Jan 4;44(D1):D481-7
pubmed: 26656494
Arch Biochem Biophys. 2016 Feb 1;591:57-65
pubmed: 26701603
Am J Physiol Endocrinol Metab. 2016 Jul 01;311(1):E236-45
pubmed: 27245335
Nucleic Acids Res. 2017 Jan 4;45(D1):D61-D67
pubmed: 27924024
Endocrinology. 2017 Sep 1;158(9):2860-2872
pubmed: 28911167
Nucleic Acids Res. 2018 Jan 4;46(D1):D661-D667
pubmed: 29136241
Proc Natl Acad Sci U S A. 2017 Dec 5;114(49):12958-12963
pubmed: 29158401
PLoS One. 2018 Feb 15;13(2):e0192606
pubmed: 29447215
Physiol Rev. 2018 Jul 1;98(3):1169-1203
pubmed: 29717933
J Clin Invest. 1996 Oct 1;98(7):1575-84
pubmed: 8833906
J Clin Invest. 1997 Mar 1;99(5):846-54
pubmed: 9062341
Biochem Biophys Res Commun. 1997 Jul 18;236(2):313-22
pubmed: 9240432
Nutrition. 1997 Sep;13(9):807-13
pubmed: 9290095
J Clin Invest. 1997 Oct 15;100(8):2115-24
pubmed: 9329978
Lancet. 1998 Jan 17;351(9097):173-7
pubmed: 9449872
J Clin Invest. 1998 Jun 1;101(11):2331-9
pubmed: 9616204
Genes Dev. 1999 Jan 1;13(1):76-86
pubmed: 9887101