Shared Genetic Risk Factors Across Carbamazepine-Induced Hypersensitivity Reactions.
Adult
Anaplastic Lymphoma Kinase
/ genetics
Carbamazepine
/ adverse effects
Chemical and Drug Induced Liver Injury
/ epidemiology
Drug Hypersensitivity
/ genetics
Drug Hypersensitivity Syndrome
/ genetics
Europe
Female
Genetic Predisposition to Disease
Genome-Wide Association Study
HLA-A Antigens
/ genetics
HLA-B Antigens
/ genetics
Humans
Male
Phenotype
Risk Factors
Stevens-Johnson Syndrome
/ genetics
Journal
Clinical pharmacology and therapeutics
ISSN: 1532-6535
Titre abrégé: Clin Pharmacol Ther
Pays: United States
ID NLM: 0372741
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
03
01
2019
accepted:
17
04
2019
pubmed:
9
5
2019
medline:
2
6
2020
entrez:
9
5
2019
Statut:
ppublish
Résumé
Carbamazepine (CBZ) causes life-threating T-cell-mediated hypersensitivity reactions, including serious cutaneous adverse reactions (SCARs) and drug-induced liver injury (CBZ-DILI). In order to evaluate shared or phenotype-specific genetic predisposing factors for CBZ hypersensitivity reactions, we performed a meta-analysis of two genomewide association studies (GWAS) on a total of 43 well-phenotyped Northern and Southern European CBZ-SCAR cases and 10,701 population controls and a GWAS on 12 CBZ-DILI cases and 8,438 ethnically matched population controls. HLA-A*31:01 was identified as the strongest genetic predisposing factor for both CBZ-SCAR (odds ratio (OR) = 8.0; 95% CI 4.10-15.80; P = 1.2 × 10
Identifiants
pubmed: 31066027
doi: 10.1002/cpt.1493
pmc: PMC7156285
mid: NIHMS1575961
doi:
Substances chimiques
HLA-A Antigens
0
HLA-B Antigens
0
Carbamazepine
33CM23913M
ALK protein, human
EC 2.7.10.1
Anaplastic Lymphoma Kinase
EC 2.7.10.1
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1028-1036Subventions
Organisme : Medical Research Council
ID : MR/L006758/1
Pays : United Kingdom
Organisme : Department of Health
ID : RP-PG-0606-1062
Pays : United Kingdom
Organisme : Wellcome Trust
ID : WT098017
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N005953/1
Pays : United Kingdom
Organisme : Department of Health
ID : 09/144/09
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0800637
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : P50 GM115305
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI139021
Pays : United States
Organisme : NIAID NIH HHS
ID : R34 AI136815
Pays : United States
Informations de copyright
© 2019 The Authors Clinical Pharmacology & Therapeutics published by Wiley Periodicals, Inc. on behalf of American Society for Clinical Pharmacology and Therapeutics.
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