Molecular characterization of dengue virus reveals regional diversification of serotype 2 in Colombia.
Adolescent
Adult
Biological Specimen Banks
Child
Child, Preschool
Colombia
/ epidemiology
Dengue
/ epidemiology
Dengue Virus
/ genetics
Female
Genetic Variation
Genotype
High-Throughput Nucleotide Sequencing
Humans
Male
Middle Aged
Phylogeny
RNA, Viral
/ blood
Retrospective Studies
Serogroup
Viral Envelope Proteins
/ genetics
Young Adult
Dengue virus
Envelope
Evolution
Molecular characterization
Phylogeny
Journal
Virology journal
ISSN: 1743-422X
Titre abrégé: Virol J
Pays: England
ID NLM: 101231645
Informations de publication
Date de publication:
08 05 2019
08 05 2019
Historique:
received:
01
03
2019
accepted:
25
04
2019
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
16
8
2019
Statut:
epublish
Résumé
Dengue is hyperendemic in Colombia, where a cyclic behavior of serotype replacement leading to periodic epidemics has been observed for decades. This level of endemicity favors accumulation of dengue virus genetic diversity and could be linked to disease outcome. To assess the genetic diversity of dengue virus type 2 in Colombia, we sequenced the envelope gene of 24 virus isolates from acute cases of dengue or severe dengue fever during the period 2013-2016. The phylogenetic analysis revealed the circulation of the Asian-American genotype of dengue virus type 2 in Colombia during that period, the intra-genotype variability leading to divergence in two recently circulating lineages with differential geographic distribution, as well as the presence of nonsynonymous substitutions accompanying their emergence and diversification.
Identifiants
pubmed: 31068191
doi: 10.1186/s12985-019-1170-4
pii: 10.1186/s12985-019-1170-4
pmc: PMC6505283
doi:
Substances chimiques
RNA, Viral
0
Viral Envelope Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
62Subventions
Organisme : NIAID NIH HHS
ID : R43 AI147744
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI045440
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI070484
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI057319
Pays : United States
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