Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism.
Adaptor Proteins, Signal Transducing
/ genetics
Animals
Calcium-Regulating Hormones and Agents
/ pharmacology
Cells, Cultured
Female
Gene Expression Regulation
/ drug effects
Glucose Transporter Type 4
/ genetics
Histone Deacetylase Inhibitors
/ pharmacology
Histone Deacetylases
/ genetics
Hydroxylamines
/ pharmacology
MEF2 Transcription Factors
/ genetics
Male
Mice
Mice, Inbred C57BL
Osteocytes
/ cytology
Parathyroid Hormone
/ pharmacology
Quinolines
/ pharmacology
MEF2
SOST
Scriptaid
bone
cell metabolism
glucose transporter type 4 (GLUT4)
histone deacetylase (HDAC)
osteocyte
parathyroid hormone
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
21 06 2019
21 06 2019
Historique:
received:
26
12
2018
revised:
02
05
2019
pubmed:
10
5
2019
medline:
4
3
2020
entrez:
10
5
2019
Statut:
ppublish
Résumé
Bone is a highly metabolic organ that undergoes continuous remodeling to maintain its structural integrity. During development, bones, in particular osteoblasts, rely on glucose uptake. However, the role of glucose metabolism in osteocytes is unknown. Osteocytes are terminally differentiated osteoblasts orchestrating bone modeling and remodeling. In these cells, parathyroid hormone (PTH) suppresses
Identifiants
pubmed: 31068415
pii: S0021-9258(20)34706-2
doi: 10.1074/jbc.RA118.007312
pmc: PMC6597811
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Calcium-Regulating Hormones and Agents
0
Glucose Transporter Type 4
0
Histone Deacetylase Inhibitors
0
Hydroxylamines
0
MEF2 Transcription Factors
0
Mef2c protein, mouse
0
Parathyroid Hormone
0
Quinolines
0
Slc2a4 protein, mouse
0
Sost protein, mouse
0
scriptaid
0
Hdac5 protein, mouse
EC 3.5.1.98
Histone Deacetylases
EC 3.5.1.98
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
9722-9733Subventions
Organisme : NIAMS NIH HHS
ID : K08 AR067285
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR060221
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK116716
Pays : United States
Organisme : NIAMS NIH HHS
ID : UH2 AR059655
Pays : United States
Informations de copyright
© 2019 Sun et al.
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