Human Pancreatic Carcinoma-Associated Fibroblasts Promote Expression of Co-inhibitory Markers on CD4
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
/ adverse effects
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Cancer-Associated Fibroblasts
/ metabolism
Costimulatory and Inhibitory T-Cell Receptors
/ genetics
Female
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Immunomodulation
Immunophenotyping
Lymphocyte Activation
/ genetics
Lymphocytes, Tumor-Infiltrating
/ immunology
Male
Middle Aged
Neoplasm Staging
Pancreatic Neoplasms
/ etiology
Tumor Burden
Pancreatic Neoplasms
PD-1
T-cells
TIM-3
cancer-associated pancreatic stellate cells
co-inhibitory markers
fibroblasts
pancreatic cancer
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2019
2019
Historique:
received:
10
12
2018
accepted:
01
04
2019
entrez:
10
5
2019
pubmed:
10
5
2019
medline:
2
10
2020
Statut:
epublish
Résumé
Carcinoma-associated pancreatic fibroblasts (CAFs) are the major type of cells in the stroma of pancreatic ductal adenocarcinomas and besides their pathological release of extracellular matrix proteins, they are also perceived as key contributors to immune evasion. Despite the known relevance of tumor infiltrating lymphocytes in cancers, the interactions between T-cells and CAFs remain largely unexplored. Here, we found that CAFs isolated from tumors of pancreatic cancer patients undergoing surgical resection (
Identifiants
pubmed: 31068935
doi: 10.3389/fimmu.2019.00847
pmc: PMC6491453
doi:
Substances chimiques
Biomarkers
0
Costimulatory and Inhibitory T-Cell Receptors
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
847Références
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