The Growth Differentiation Factor-15 (GDF-15) levels are increased in patients with compound heterozygous sickle cell and beta-thalassemia (HbS/β
Adult
Aged
Aged, 80 and over
Anemia, Sickle Cell
/ blood
Biomarkers
Blood Coagulation
Cytokines
/ metabolism
Endothelial Cells
Female
Growth Differentiation Factor 15
/ blood
Hemolysis
Heterozygote
Humans
Hypertension, Pulmonary
/ diagnosis
Iron
/ blood
Male
Middle Aged
Young Adult
beta-Globins
/ genetics
beta-Thalassemia
/ blood
Endotheial dysfunction
GDF-15
Sickle Cell Disease
βthalassaemia
Journal
Blood cells, molecules & diseases
ISSN: 1096-0961
Titre abrégé: Blood Cells Mol Dis
Pays: United States
ID NLM: 9509932
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
25
02
2019
revised:
22
04
2019
accepted:
22
04
2019
pubmed:
10
5
2019
medline:
15
1
2020
entrez:
10
5
2019
Statut:
ppublish
Résumé
The clinical manifestations of Sickle Cell Disease (SCD) include episodes of vascular occlusion, chronic hemolytic anemia and frequent infections. GDF-15, a multifactorial cytokine, is a member of the transforming growth factor- superfamily. Expression of the GDF-15 gene in cardiomyocytes, vascular smooth muscle cells, and endothelial cells is strongly upregulated in response to oxidative stress, inflammation and tissue injury, while high levels of serum GDF-15 associate with ineffective erythropoiesis and may reflect a certain type of bone marrow stress or erythroblast apoptosis. In this context we aimed to evaluate GDF-15 levels in 89 patients with HbS/β
Identifiants
pubmed: 31071550
pii: S1079-9796(19)30087-7
doi: 10.1016/j.bcmd.2019.04.011
pii:
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
GDF15 protein, human
0
Growth Differentiation Factor 15
0
beta-Globins
0
Iron
E1UOL152H7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
137-141Informations de copyright
Copyright © 2019. Published by Elsevier Inc.