Evaluation of equine articular cartilage degeneration after mechanical impact injury using cationic contrast-enhanced computed tomography.

Animals Cancellous Bone / diagnostic imaging Cartilage, Articular / diagnostic imaging Chondrocytes / pathology Coloring Agents Compressive Strength Contrast Media Glycosaminoglycans / metabolism Horses Magnetic Resonance Imaging Models, Animal Osteoarthritis, Knee Phenazines Stifle / injuries Synovial Membrane / pathology X-Ray Microtomography
Biochemical Cartilage imaging Glycosaminoglycan Histology Osteoarthritis Post traumatic OA

Journal

Osteoarthritis and cartilage
ISSN: 1522-9653
Titre abrégé: Osteoarthritis Cartilage
Pays: England
ID NLM: 9305697

Informations de publication

Date de publication:
08 2019
Historique:
received: 13 12 2018
revised: 13 04 2019
accepted: 16 04 2019
pubmed: 11 5 2019
medline: 26 8 2020
entrez: 11 5 2019
Statut: ppublish

Résumé

Cationic agent contrast-enhanced computed tomography (cationic CECT) characterizes articular cartilage ex vivo, however, its capacity to detect post-traumatic injury is unknown. The study objectives were to correlate cationic CECT attenuation with biochemical, mechanical and histological properties of cartilage and morphologic computed tomography (CT) measures of bone, and to determine the ability of cationic CECT to distinguish subtly damaged from normal cartilage in an in vivo equine model. Mechanical impact injury was initiated in equine femoropatellar joints in vivo to establish subtle cartilage degeneration with site-matched controls. Cationic CECT was performed in vivo (clinical) and postmortem (microCT). Articular cartilage was characterized by glycosaminoglycan (GAG) content, biochemical moduli and histological scores. Bone was characterized by volume density (BV/TV) and trabecular number (Tb.N.), thickness (Tb.Th.) and spacing (Tb.Sp.). Cationic CECT attenuation (microCT) of cartilage correlated with GAG (r = 0.74, P < 0.0001), compressive modulus (E Cationic CECT (microCT) reflects articular cartilage properties enabling segregation of subtly degenerated from healthy tissue and also reflects bone morphometric properties on CT. Cationic CECT is capable of characterizing articular cartilage in clinical scanners.

Identifiants

DOI: 10.1016/j.joca.2019.04.015 PMID: 31075424
pubmed: 31075424
pii: S1063-4584(19)30962-8
doi: 10.1016/j.joca.2019.04.015
pii:
doi:

Substances chimiques

Coloring Agents 0
Contrast Media 0
Glycosaminoglycans 0
Phenazines 0
safranine T XTX0YXU2HV

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1219-1228

Informations de copyright

Copyright © 2019 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

Auteurs

B B Nelson (BB)

Equine Orthopaedic Research Center, Colorado State University, Fort Collins, CO, USA.

J T A Mäkelä (JTA)

Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; Department of Chemistry, Boston University, Boston, MA, USA.

T B Lawson (TB)

Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA; Department of Mechanical Engineering, Boston University, Boston, MA, USA.

A N Patwa (AN)

Department of Chemistry, Boston University, Boston, MA, USA; SLSE (Chemistry), Navrachana University, Vadodara, Gujarat, India.

M F Barrett (MF)

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA.

C W McIlwraith (CW)

Equine Orthopaedic Research Center, Colorado State University, Fort Collins, CO, USA.

M B Hurtig (MB)

Department of Clinical Studies, University of Guelph, Ontario, Canada.

B D Snyder (BD)

Center for Advanced Orthopaedic Studies, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA.

V J Moorman (VJ)

Equine Orthopaedic Research Center, Colorado State University, Fort Collins, CO, USA.

M W Grinstaff (MW)

Department of Chemistry, Boston University, Boston, MA, USA; Department of Mechanical Engineering, Boston University, Boston, MA, USA; Departments of Biomedical Engineering, and Medicine, Boston University, Boston, MA, USA.

L R Goodrich (LR)

Equine Orthopaedic Research Center, Colorado State University, Fort Collins, CO, USA.

C E Kawcak (CE)

Equine Orthopaedic Research Center, Colorado State University, Fort Collins, CO, USA. Electronic address: ckawcak@colostate.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Evaluation of equine articular cartilage...
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Os spongieux › Evaluation of equine articular cartilage...
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Cartilage articulaire › Evaluation of equine articular cartilage...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Chondrocytes › Evaluation of equine articular cartilage...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Agents colorants › Evaluation of equine articular cartilage...
questionsmedicales.fr › Phénomènes physiques › Phénomènes mécaniques › Résistance à la compression › Evaluation of equine articular cartilage...
questionsmedicales.fr › Actions chimiques et utilisations › Utilisations spécialisées de produits chimiques › Produits de contraste › Evaluation of equine articular cartilage...
questionsmedicales.fr › Glucides › Polyosides › Glycosaminoglycanes › Evaluation of equine articular cartilage...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Perissodactyla › Equidae › Equus caballus › Evaluation of equine articular cartilage...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Evaluation of equine articular cartilage...
questionsmedicales.fr › Techniques d'investigation › Modèles animaux › Evaluation of equine articular cartilage...
questionsmedicales.fr › Maladies ostéomusculaires › Arthrose › Gonarthrose › Evaluation of equine articular cartilage...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérocycliques 3 noyaux › Phénazines › Evaluation of equine articular cartilage...
questionsmedicales.fr › Structures anatomiques de l'animal › Membre pelvien › Grasset › Evaluation of equine articular cartilage...
questionsmedicales.fr › Appareil locomoteur › Squelette › Articulations › Capsule articulaire › Membrane synoviale › Evaluation of equine articular cartilage...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Microtomographie aux rayons X › Evaluation of equine articular cartilage...