Systemic glucocorticoid usage in dogs under primary veterinary care in the UK: prevalence and risk factors.


Journal

The Veterinary record
ISSN: 2042-7670
Titre abrégé: Vet Rec
Pays: England
ID NLM: 0031164

Informations de publication

Date de publication:
27 07 2019
Historique:
received: 09 10 2018
revised: 28 02 2019
accepted: 22 04 2019
pubmed: 12 5 2019
medline: 21 7 2020
entrez: 12 5 2019
Statut: ppublish

Résumé

Glucocorticoids are widely used in primary care veterinary practices. The study aimed to quantify the usage of systemic glucocorticoids (SGC) in dogs in the UK using primary care treatment records recorded during 2013 in the VetCompass Programme. From a study population of 455 557 dogs, 28 472 dogs (6.2 per cent, 95 per cent CI 6.2 to 6.3) received a total of 50 971 SGC therapy events in 2013. Prednisolone represented the most frequently used oral preparation (27 362 events, 90.0 per cent of oral events). Dexamethasone sodium phosphate was the most commonly used injectable agent (12 796 events, 62.7 per cent of injectable events). The most common breed treated was Staffordshire Bull Terriers (2236/28 472 dogs, 7.9 per cent, 95 per cent CI 7.5 to 8.2) and within-breed prevalence of SGC usage was 2236/32 635, 6.9 per cent, 95 per cent CI 6.6 to 7.1. The most commonly treated age group was dogs older than eight years (8931/28472, 31.4 per cent) and the most commonly treated bodyweight group was 10.01-20.0 kg (7918/28 472, 27.8 per cent). Dexamethasone and prednisolone were the most commonly prescribed SGC. Short-acting and intermediate-acting injectable SGC were more commonly used compared with long-acting injectable SGC. Older and medium size dogs were most likely to receive SGC and certain breeds appeared predisposed. These data can provide a useful benchmark for glucocorticoid usage and highlight the benefits from 'Big Data' analyses.

Identifiants

pubmed: 31076520
pii: vr.105220
doi: 10.1136/vr.105220
doi:

Substances chimiques

Glucocorticoids 0
Prednisolone 9PHQ9Y1OLM

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108

Informations de copyright

© British Veterinary Association 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: None declared.

Auteurs

Doaa A Elkholly (DA)

Pathobiology and Population Science, Royal Veterinary College, Hatfield, UK.

Dan O'Neill (D)

Veterinary Clinical Sciences, Royal Veterinary College, Hatfield, UK.

Andrea K Wright (AK)

Zoetis, Dublin, Ireland.

Kennedy Mwacalimba (K)

Zoetis, Parsippany, New Jersey, USA.

Laura S Nolan (LS)

Zoetis, Tadworth, UK.

Amy Pavlock (A)

Zoetis, Tadworth, UK.

Ludovic Pelligand (L)

Department of Pharmacology, Royal Veterinary College, Hatfield, UK.

David Church (D)

Royal Veterinary College, London, UK.

David C Brodbelt (DC)

Veterinary Clinical Sciences, Royal Veterinary College, Hatfield, UK.

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Classifications MeSH