Medroxyprogesterone acetate affects sex differentiation and spermatogenesis in zebrafish.
Animals
Brain
/ drug effects
Female
Gene Expression Regulation, Developmental
/ drug effects
Gonads
/ drug effects
Hormones
/ blood
Male
Medroxyprogesterone Acetate
/ pharmacology
Pituitary Gland
/ drug effects
Sex Differentiation
/ drug effects
Sex Ratio
Spermatogenesis
/ drug effects
Transcription, Genetic
/ drug effects
Water Pollutants, Chemical
/ toxicity
Zebrafish
/ blood
Chronic exposure
Gonad development
Medroxyprogesterone acetate
Sex differentiation
Zebrafish
Journal
Aquatic toxicology (Amsterdam, Netherlands)
ISSN: 1879-1514
Titre abrégé: Aquat Toxicol
Pays: Netherlands
ID NLM: 8500246
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
28
12
2018
revised:
15
04
2019
accepted:
16
04
2019
pubmed:
12
5
2019
medline:
25
7
2019
entrez:
12
5
2019
Statut:
ppublish
Résumé
Medroxyprogesterone acetate (MPA) is a widely used synthetic progestin and it has been frequently detected in aquatic environments. However, its effects on aquatic organisms remain largely unknown. Here we investigated the chronic effects of MPA on sex differentiation and gonad development in zebrafish. Zebrafish larvae at 20 days post fertilization (dpf) were exposed to 4.32, 42.0, and 424 ng L
Identifiants
pubmed: 31077968
pii: S0166-445X(18)31144-5
doi: 10.1016/j.aquatox.2019.04.014
pii:
doi:
Substances chimiques
Hormones
0
Water Pollutants, Chemical
0
Medroxyprogesterone Acetate
C2QI4IOI2G
Types de publication
Journal Article
Langues
eng
Pagination
70-76Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.