Radiation-Induced DNA Damage Cooperates with Heterozygosity of TP53 and PTEN to Generate High-Grade Gliomas.
Animals
Brain Neoplasms
/ genetics
DNA Breaks, Double-Stranded
Female
Glioblastoma
/ genetics
Glioma
/ genetics
Humans
Linear Energy Transfer
Loss of Heterozygosity
Male
Mice
Mice, Inbred C57BL
Neoplasm Grading
Neoplasms, Radiation-Induced
/ genetics
Neoplastic Stem Cells
/ pathology
PTEN Phosphohydrolase
/ genetics
Tumor Suppressor Protein p53
/ genetics
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 07 2019
15 07 2019
Historique:
received:
05
03
2019
revised:
08
04
2019
accepted:
10
05
2019
pubmed:
16
5
2019
medline:
9
4
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
Glioblastomas are lethal brain tumors that are treated with conventional radiation (X-rays and gamma rays) or particle radiation (protons and carbon ions). Paradoxically, radiation is also a risk factor for GBM development, raising the possibility that radiotherapy of brain tumors could promote tumor recurrence or trigger secondary gliomas. In this study, we determined whether tumor suppressor losses commonly displayed by patients with GBM confer susceptibility to radiation-induced glioma. Mice with Nestin-Cre-driven deletions of
Identifiants
pubmed: 31088835
pii: 0008-5472.CAN-19-0680
doi: 10.1158/0008-5472.CAN-19-0680
pmc: PMC6635038
mid: NIHMS1529678
doi:
Substances chimiques
TP53 protein, human
0
Trp53 protein, mouse
0
Tumor Suppressor Protein p53
0
PTEN Phosphohydrolase
EC 3.1.3.67
PTEN protein, human
EC 3.1.3.67
Pten protein, mouse
EC 3.1.3.67
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
3749-3761Subventions
Organisme : NCI NIH HHS
ID : R01 CA149461
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA197796
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA205224
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM109645
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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