Association between insomnia disorder and cognitive function in middle-aged and older adults: a cross-sectional analysis of the Canadian Longitudinal Study on Aging.
Aged
Aging
Anxiety
/ psychology
Anxiety Disorders
/ psychology
Canada
Cognition
/ physiology
Comorbidity
Cross-Sectional Studies
Depression
/ psychology
Executive Function
/ physiology
Female
Health Status
Humans
Longitudinal Studies
Male
Memory
/ physiology
Middle Aged
Neuropsychological Tests
Sleep
/ physiology
Sleep Initiation and Maintenance Disorders
/ physiopathology
Surveys and Questionnaires
CLSA
aging
cognition
cohort
insomnia
Journal
Sleep
ISSN: 1550-9109
Titre abrégé: Sleep
Pays: United States
ID NLM: 7809084
Informations de publication
Date de publication:
01 08 2019
01 08 2019
Historique:
received:
06
12
2018
revised:
27
02
2019
pubmed:
16
5
2019
medline:
1
5
2020
entrez:
16
5
2019
Statut:
ppublish
Résumé
This study examined the differences in cognitive function between middle-aged and older adults with insomnia disorder, insomnia symptoms only (ISO) or no insomnia symptoms (NIS), in the context of other health and lifestyle factors. Twenty-eight thousand four hundred eighty-five participants >45 years completed questionnaires, physical examinations, and neuropsychological testing across domains of processing speed, memory, and executive functions. An eight-question instrument assessed participants' sleep, defining subjects with insomnia symptoms, probable insomnia disorder (PID), or NIS. The associations between these three groups and cognitive performance were examined with linear regression models adjusted for lifestyle and clinical factors. PID was identified in 1,068 participants (3.7% of the sample) while 7,813 (27.5%) experienced ISO. Participants with PID exhibited greater proportions of adverse medical and lifestyle features such as anxiety, depression, and diabetes than both other groups. Analyses adjusting for age, sex, education, as well as medical and lifestyle factors demonstrated that adults with PID exhibited declarative memory deficits (Rey Auditory Verbal Learning Test) compared with ISO or NIS. Adults with insomnia symptoms exhibited better performance on a task of mental flexibility than both other groups. These findings suggest that insomnia disorder in middle-aged and older adults is associated with poorer health outcomes and worse memory performance than adults with insomnia symptoms alone or without any sleep complaints, even after adjustment for comorbidities. The assessment of longitudinal data within this cohort will be critical to understand if insomnia disorder may increase the risk of further cognitive decline.
Identifiants
pubmed: 31089710
pii: 5488740
doi: 10.1093/sleep/zsz114
pmc: PMC6685318
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : CIHR
ID : LSA 9447
Pays : Canada
Organisme : CIHR
ID : FDN154291
Pays : Canada
Organisme : CIHR
ID : MOP 142191
Pays : Canada
Organisme : CIHR
ID : PJT 153115
Pays : Canada
Organisme : CIHR
ID : PJT 156125
Pays : Canada
Informations de copyright
© Sleep Research Society 2019. Published by Oxford University Press on behalf of the Sleep Research Society. All rights reserved. For permissions, please e-mail journals.permissions@oup.com.
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