[From panel diagnostics to comprehensive genomic analysis : Infobesity or empowerment?]
Von der Paneldiagnostik zu umfassenden genomischen Analysen : Informationsüberfluss oder Zugewinn?
DNA copy number variations
DNA mutational analysis
Gene expression profiling
High-throughput nucleotide sequencing
Whole genome sequencing
Journal
Der Pathologe
ISSN: 1432-1963
Titre abrégé: Pathologe
Pays: Germany
ID NLM: 8006541
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
pubmed:
16
5
2019
medline:
23
8
2019
entrez:
16
5
2019
Statut:
ppublish
Résumé
Precision oncology is obtaining a central role in the therapy of malignant diseases. The indication for targeted therapy is based on the identification of molecular targets for which next-generation sequencing (NGS) is commonly used nowadays. All approved predictive biomarkers and molecular targets, including gene fusions and copy number alterations, can be identified depending on panel design and method applied. Some clinical scenarios, however, may require more holistic genomic approaches, such as whole-genome/whole-exome and transcriptome analysis, which must be embedded in a clinical trial. Here, key aspects and applications of each method are summarized and discussed.
Identifiants
pubmed: 31089797
doi: 10.1007/s00292-019-0608-1
pii: 10.1007/s00292-019-0608-1
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
ger
Pagination
235-242Références
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