Trauma-induced Rejection in Vascularized Composite Allotransplantation.


Journal

Annals of surgery
ISSN: 1528-1140
Titre abrégé: Ann Surg
Pays: United States
ID NLM: 0372354

Informations de publication

Date de publication:
05 2020
Historique:
pubmed: 16 5 2019
medline: 24 6 2020
entrez: 16 5 2019
Statut: ppublish

Résumé

: Vascularized composite allotransplantation (VCA) is a relatively new field in reconstructive medicine. Likely a result of the unique tissue composition of these allografts-including skin and often a bone marrow component-the immunology and rejection patterns do not always mimic those of the well-studied solid organ transplantations. While the number and type of VCAs performed is rapidly expanding, there is still much to be discovered and understood in the field. With more patients, new findings and patterns emerge and add to our understanding of VCA. Here, we present a case report of an upper extremity transplant recipient with trauma-induced rejection.

Identifiants

pubmed: 31090564
doi: 10.1097/SLA.0000000000003365
pii: 00000658-202005000-00029
doi:

Substances chimiques

Immunosuppressive Agents 0

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e113-e114

Commentaires et corrections

Type : CommentIn

Références

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Etra JW, Raimondi G, Brandacher G. Mechanisms of rejection in vascular composite allotransplantation. Curr Opin Organ Transplant 2018; 23:28–33.
Petruzzo P, Sardu C, Lanzetta M, et al. Report (2017) of the International Registry on Hand and Composite Tissue Allotransplantation (IRHCTT). Curr Transpl Rep 2017; 4:294–303.
Kaufman CL, Ouseph R, Blair B, et al. Graft vasculopathy in clinical hand transplantation. Am J Transplant 2012; 12:1004–1016.
Schneeberger S, Gorantla VS, van Riet RP, et al. Atypical acute rejection after hand transplantation. Am J Transplant 2008; 8:688–696.
Schneeberger S, Gorantla VS, Brandacher G, et al. Upper-extremity transplantation using a cell-based protocol to minimize immunosuppression. Ann Surg 2013; 257:345–351.
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Starzl R, Brandacher G, Lee WPA, et al. Review of the early diagnoses and assessment of rejection in vascularized composite allotransplantation. Clin Dev Immunol 2013; 2013:402980.
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Christensen J, Ibrahim Z, Wu L, et al. Mechanical trauma can reactivate an alloimmune response against the skin-component in a large animal vascularized composite allotransplantation (VCA) model of operational tolerance [abstract]. Am J Transpl 2013; 13: (suppl 5): 560.
Wolfram D, Morandi EM, Eberhart N, et al. Differentiation between acute skin rejection in allotransplantation and T-cell mediated skin inflammation based on gene expression analysis. Biomed Res Int 2015; 2015:259160.
Hautz T, Wolfram D, Grahammer J, et al. Mechanisms and mediators of inflammation: potential models for skin rejection and targeted therapy in vascularized composite allotransplantation. Clin Dev Immunol 2012; 2012:757310.

Auteurs

Joanna W Etra (JW)

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Jaimie T Shores (JT)

Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Inbal B Sander (IB)

Department of Dermatology, Division of Dermatopathology, Johns Hopkins University School of Medicine, Baltimore, MD.

Gerald Brandacher (G)

Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

W P Andrew Lee (WPA)

Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Current address: University of Texas Southwestern Medical Center, Dallas, TX.

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