Adenosine-Functionalized Biodegradable PLA-b-PEG Nanoparticles Ameliorate Osteoarthritis in Rats.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
15 05 2019
15 05 2019
Historique:
received:
20
02
2018
accepted:
02
05
2019
entrez:
17
5
2019
pubmed:
17
5
2019
medline:
6
11
2020
Statut:
epublish
Résumé
Short biologic half-lives limit the therapeutic utility of many small molecules. One approach to extending the half-life of pharmacologically active small molecules is conjugation to less degradable nanoparticles; here we report the synthesis and activity of six targeted polymeric (PEG-b-PLA) nanoparticles for use as adenosine receptor agonists. Using click chemistry, PLA-b-PEG400-N
Identifiants
pubmed: 31092864
doi: 10.1038/s41598-019-43834-y
pii: 10.1038/s41598-019-43834-y
pmc: PMC6520388
doi:
Substances chimiques
Lactates
0
Polymers
0
Purinergic P1 Receptor Agonists
0
poly(lactic acid-ethylene glycol)
0
Polyethylene Glycols
3WJQ0SDW1A
polyethylene glycol 400
B697894SGQ
Adenosine
K72T3FS567
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7430Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR054897
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR056672
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000038
Pays : United States
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